ID   A0A3B3YQD8_9TELE        Unreviewed;       678 AA.
AC   A0A3B3YQD8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=RHD domain-containing protein {ECO:0000259|PROSITE:PS50254};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000029250.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000029250.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3YQD8; -.
DR   Ensembl; ENSPMET00000020130.1; ENSPMEP00000029250.1; ENSPMEG00000014930.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07881; RHD-n_NFAT; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR008366; NFAT.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR12533; NFAT; 1.
DR   PANTHER; PTHR12533:SF5; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR01789; NUCFACTORATC.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   4: Predicted;
FT   DOMAIN          383..565
FT                   /note="RHD"
FT                   /evidence="ECO:0000259|PROSITE:PS50254"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..276
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   678 AA;  74668 MW;  69BF30361B3802B5 CRC64;
     MSSQQEEQEF DFSYLFEDSQ AAQNEPDRDA YNYTPNVSLP IGMGNPCLST QYHTLQSSPV
     IPVSSCHQTG YSVQNDNHAA SSYYLPQALR PNGAPALESP RIEITAYSQY PEDEVEASGR
     EDHIIKRGVN SIVTLTLPNV DGYRDPSCLS PASSISSRSC NSEASSYESG FYNYDNSPQN
     SPWQSPSVSP RGSSSLLSCP HAIGPAASPH HSPSNSPQIG AMAEEGWPAQ PRGSRPNSPS
     CSGRKYSFSG SSYQQTSCSP NQSPTPSSHG SPRVSVTDEN WLTNTNQYTN LAIVAAINAL
     TTDGMADMAE GIPIKTRKTM LDLSPSMSLK VEPGGEDLGP EGELRHEEYP SRLSLKKENY
     CGGFLDVPQH PYSWSKPKPY LSPSLPALDW QLPSCSGPYN LQIEVQPKSH HRAHYETEGS
     RGAVKALSGG HPVVQLYGYM ESEPLTLQLF IGTADDRLLR PHAFYQVHRI TGKTVSTASH
     EVMQSNTKIL EIPLLPENNM RAIIDCAGIL KLRNSDIELR KGETDIGRKN TRVRLVFRVH
     INQPNGRTVS LQVASNPIEC SQRSAQELPL VEKQSVESYP ATGGKMMLLG GLNFLPESKV
     VFVEKAQDGH HLWETEAKVD KDSVKTNTLV VEIPPYRNQR ISSPVQVNFY VCNGKRKRSQ
     YQRFTYVPAN GNPQPDLL
//