ID A0A3B3YT87_9TELE Unreviewed; 365 AA.
AC A0A3B3YT87;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF {ECO:0000256|PIRNR:PIRNR037866};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000030671.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000030671.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Scaffold protein that connects plasma membrane proteins with
CC members of the ezrin/moesin/radixin family and thereby helps to link
CC them to the actin cytoskeleton and to regulate their surface
CC expression. {ECO:0000256|PIRNR:PIRNR037866}.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus
CC {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184,
CC ECO:0000256|PIRNR:PIRNR037866}.
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DR AlphaFoldDB; A0A3B3YT87; -.
DR STRING; 48701.ENSPMEP00000030671; -.
DR Ensembl; ENSPMET00000032749.1; ENSPMEP00000030671.1; ENSPMEG00000017409.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 2.
DR InterPro; IPR015098; EBP50_C.
DR InterPro; IPR017300; NHERF-1/NHERF-2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14191:SF7; NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF1; 1.
DR PANTHER; PTHR14191; PDZ DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF09007; EBP50_C; 1.
DR Pfam; PF00595; PDZ; 2.
DR PIRSF; PIRSF037866; EBP50; 1.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR PROSITE; PS50106; PDZ; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Membrane {ECO:0000256|PIRNR:PIRNR037866}.
FT DOMAIN 8..88
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 152..232
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 107..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 39285 MW; E8FB1DC59C759E2F CRC64;
MSHLRPRLCV LEKSPTGYGF HLHAEKGRTG QFIRLVEPDS PASASGLLAR DRLMFVNGEN
VEGESHQQVV ARIRATTGAL ELIVVDPETA ELLSKHDLRC RKEYVTEGIP LPGGDSDSEH
EDKRSNGTPV PRENGDTSSV SSGSRDGPRP RLCHMKKGSG GYGFNLHSEK NKPGQFIRAV
DDDSPAQRAG LRPQDKILQV NGVSVIGLQH TEVVAAIKAN GDETTLLVVD AEAEEFFKKC
NVQPGEEHVT GKTSPRPVRC PEGEHGVSSQ LKSKLSVSSQ ASSASSNASQ PAADRSPSPP
QVGFAGNLRS ILPERTPEPE PSPSGDAIGL SLSLAQAKER AHQKRAAKKA PPMDWSKRNE
LFSNL
//