ID   A0A3B3YVL6_9TELE        Unreviewed;       618 AA.
AC   A0A3B3YVL6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Ectonucleoside triphosphate diphosphohydrolase 4 {ECO:0008006|Google:ProtNLM};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000031060.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000031060.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   RefSeq; XP_014859290.1; XM_015003804.1.
DR   RefSeq; XP_014859291.1; XM_015003805.1.
DR   RefSeq; XP_014859292.1; XM_015003806.1.
DR   RefSeq; XP_014859293.1; XM_015003807.1.
DR   AlphaFoldDB; A0A3B3YVL6; -.
DR   STRING; 48701.ENSPMEP00000031060; -.
DR   Ensembl; ENSPMET00000023670.1; ENSPMEP00000031060.1; ENSPMEG00000017962.1.
DR   GeneID; 106927908; -.
DR   KEGG; pmei:106927908; -.
DR   CTD; 9583; -.
DR   OrthoDB; 180318at2759; -.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF29; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        566..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        222
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         274..278
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   618 AA;  70287 MW;  36EEAC3F1B9ED270 CRC64;
     MGRIGFSCLF PASWHFSLSS QVLPRLLTPS FRQLLFIGLV LCLIGLLYLL LVAVNTHTSW
     TGEENPFHRH LARVTDLDAT DTSNPNLNYG LVVDCGSSGS RVFVYCWPRH NGNPRELLDI
     RQMRDQHRKP VVMKIKPGIA ELAKTPEKAS DYIDPLLSFA AQHIPKHKHQ ETPLYILCTA
     GMRILPESQQ EAILEDLRTD IPVHFNFLFS DSHVEVISGK QEGVYAWIGI NFVLGRFNHV
     DNDGEAVVEV NVPGTDHQEA LMRKRTAGVL DMGGVSTQIA YEVPKTVSFA SPQQEEVAKN
     LLAEFNLGCD AHVTDHVYRV YVSTFLGFGG NAARQRYEEN LIRNAAARNK LLGEHVGETA
     ESPLLDPCLP TDLLDEIGPS TQRLHLRGTG DFDECRRILQ PFLNRTNDTQ TSLSGIYQPA
     IDYSNSQFYG FSEFYYCMED VLRMGGNYNA SKYARAAKGY CATQWKTLKE RFDSGLYASH
     ADFHRLKYQC FKSAWMYEVL HTGFSFPTNY KNLKTALLVY DKEVQWTLGA ILYRTRFLPL
     RDIPQESLKG AHSHWRHSFS FVNNHYLFPA CFFIVLLSII LYLLRLRRIH RRVAQRYTPS
     SVPWLEEGLA SPSLPINL
//