ID   A0A3B3Z386_9TELE        Unreviewed;       690 AA.
AC   A0A3B3Z386;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000034181.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000034181.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3Z386; -.
DR   Ensembl; ENSPMET00000029667.1; ENSPMEP00000034181.1; ENSPMEG00000000793.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 6.10.140.210; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR   Pfam; PF21022; Rap-GAP_dimer; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          213..429
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          80..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          477..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..520
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..563
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        565..580
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..657
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   690 AA;  75615 MW;  02E591009B90E7E6 CRC64;
     MLRRRRSATF SGFGWIDKST LSALKGRKQE LLNISNVPLG ECPPSPPRTA PPSMKVLEKG
     GPYPQVILPQ FGGYWIEDAE APAGTPSSSE SSFCEEEDGD EGMSPGGAHS YRLECNSTAR
     AYRKHFLGKE HMNYYCSGSS IGNLIMSLKH EEAQGQEFLR IMLRSRTKTV HDRISLAGIS
     QLPSVPQIAK LLCDDATGLR FSPVLYPRGS QLIVAYDEHE VNNTFKFGVI YQKFGQTSEE
     ELFGNNEETP AFKEFLSILG DNIELQDFKG FRGGLDVSHG QTGSESVYTV FRHREIMFHV
     STKLPFTEGD VQQLQRKRHI GNDIVAAVFQ EESTPFVPDM IASNFLHAYV LVQVENPCTD
     HTTYKVSVTA REDVPPFGPP LPNPAVFTKG PEFREFLLTK LINAENACYK SDKFAKLEGR
     TRAALLDNLH DELHRQSQAV LGLGQMGEED KLENGGHGGL LESFKRAMRV RSHSMETVVG
     SHRHRSPGVA GGVPASLSGG GLPQSTSECT KSTFTPPVLS AKSPLKSPVK RRSGLFPRLH
     SSTDAPSDKH TRSDHKPAEI CPHSQEVRSE TSSNPSSPEI CPNKERPFIK HKECSSGSSC
     RPNISRSSSS TSSFSSTTGE TEVLEELETV SHPSITSTSA FSPALSIDSQ GSGTPVIMCR
     SPTDGKGKTS PRSSLKFRFD KMSHSSTASE
//