ID   A0A3B3Z4F0_9TELE        Unreviewed;       822 AA.
AC   A0A3B3Z4F0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Bromodomain-containing protein 2 {ECO:0000256|ARBA:ARBA00040998};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000034497.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000034497.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBUNIT: Homodimer. Interacts with E2F1 and with histone H4 acetylated
CC       at 'Lys-13'. {ECO:0000256|ARBA:ARBA00038820}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_014822481.1; XM_014966995.1.
DR   AlphaFoldDB; A0A3B3Z4F0; -.
DR   STRING; 48701.ENSPMEP00000034497; -.
DR   Ensembl; ENSPMET00000030300.1; ENSPMEP00000034497.1; ENSPMEG00000023790.1.
DR   GeneID; 106903294; -.
DR   KEGG; pmei:106903294; -.
DR   OrthoDB; 152619at2759; -.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd05497; Bromo_Brdt_I_like; 1.
DR   CDD; cd05498; Bromo_Brdt_II_like; 1.
DR   Gene3D; 1.20.1270.220; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR   InterPro; IPR043508; Bromo_Brdt_I.
DR   InterPro; IPR043509; Bromo_Brdt_II.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR027353; NET_dom.
DR   InterPro; IPR038336; NET_sf.
DR   PANTHER; PTHR22880:SF240; BROMODOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR   Pfam; PF17035; BET; 1.
DR   Pfam; PF00439; Bromodomain; 2.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 2.
DR   SUPFAM; SSF47370; Bromodomain; 2.
DR   PROSITE; PS00633; BROMODOMAIN_1; 2.
DR   PROSITE; PS50014; BROMODOMAIN_2; 2.
DR   PROSITE; PS51525; NET; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW   ProRule:PRU00035}; Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          87..159
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          386..458
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          651..733
FT                   /note="NET"
FT                   /evidence="ECO:0000259|PROSITE:PS51525"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          47..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          559..655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          726..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..240
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..514
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..589
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        590..606
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        726..763
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        791..822
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   822 AA;  91219 MW;  DEF3165E52FA86F5 CRC64;
     MEAAVNPPQD SSLVGLSSGM LDQHCSSGKR IRKPSLLYED FESPSLPHTM TQATPAPPQP
     PVKDPSRPGR MTNQLQYLQK TLIKCLWRHH FAWPFHEPVD AYRLNLPDYY KIIKQPMDMG
     TIKKRLENNF YQSAGECIQD FNTMFTNCYI YNKPTDDIVL MAQSLEKIFL QKVAQMPQEE
     VELPPPAPRS KNSRGRGRKS NPSRAQQVPA VSQSAYSPSS SDTGDSMLAS SPQTVLTKSL
     PPANIMGLPP TQPTTKKKGV KRKADTTTPS TLGFTVGMSG STHMVGLGKG GHGGQVHDTS
     MHTISSMGSM SLETPPGMGL VRSSGGPVLL QPMMAGTGRR VGSGRPIKPP KKDLPDSVQP
     QLSKKGKLSP QLRYCSGLLK EMLSKKHAAY AWPFYTPVDT TALGLHDYHD IIKCPMDLST
     IKRKMDCREY RDAQQFASDV RLMFSNCYKY NPPDHDVVAM ARKLQDVFEF RFAKMPDEPP
     MEHTAMSVIG HPTSSSSSSS SSSSSSSSTS ESEPSSDSEE SESSLSSDSE EERAHRLAEL
     QDQVCTQLRA VHEQLAALSQ GPIVKPKKKK EKKEKKEKKK KKKIEKRSRV GRSRAGSEEW
     KMPGKMLKSK SARAGVSQVK RVQTKKSNKN SKTAKKPFYP TLAPSTLPHY DSEEEEEIVP
     MTYDEKRQLS LDINKLPGEK LGRVVHIIQS REPSLRDTNP EEIEIDFETL KPSTLKELER
     YVMTCLRKKP RKPYGEPEVK NKGSMSKEEL TLEKRRELER RLQDVSGQLN SVKKPTKPKV
     EKPSAVEAHA QPSRLSGSSS SSDSSSSSSS SSSSDTSDSD ST
//