ID   A0A3B3Z6K1_9GOBI        Unreviewed;       905 AA.
AC   A0A3B3Z6K1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000000227.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000000227.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   AlphaFoldDB; A0A3B3Z6K1; -.
DR   STRING; 409849.ENSPMGP00000000227; -.
DR   Ensembl; ENSPMGT00000000241.1; ENSPMGP00000000227.1; ENSPMGG00000000248.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   PANTHER; PTHR24365:SF525; TOLL-LIKE RECEPTOR 5; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   Pfam; PF01582; TIR; 1.
DR   SMART; SM00365; LRR_SD22; 6.
DR   SMART; SM00369; LRR_TYP; 10.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        676..699
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          727..872
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          875..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        875..891
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   905 AA;  103310 MW;  D6D11F268698EA7D CRC64;
     MFLLRYKILA WLKPHERQFC VIQVLKYQTY CKIKCVVFLQ VSVVAPCEMF GVIAQCSFKN
     LSEVPVLPSY TEHLYLDHNS ISELNSTSLR DLRFLERLDL GAQRVPLVIR NNAFLRQQRL
     KTLILGLNHD LTLEPRAFAG LSGLQELDLV YCDLTDSILS ENYLQPLWSL YKLDLSYNNI
     KRVRPAKFFQ FSNVKEIILV LNQIDTLCEE DLAGFQGKHF TLFNIASNHL YETMLQPNFN
     WTACRNPFKY MSFDTLDLSG VGFNATSLQR FLNAIDGTPI KSLHYSGYLG RGFSFQNLLD
     PDKDTFKGLQ NSSVEVLDLA DNFIFSLQAL VFSPLTKAIT IDVAKNKINQ IHPHAFSGLQ
     NSLRMLNLSF NLLGEIYSST FELLTDLRIL DLSYNHIGAL GYEAFKGLPS LKLLSLEGNS
     LRTLGSTAYL PDLLYLYLGD NRLSSLTGMT DFTGKSITYL DVKDNRLTLL DELFYIGAHF
     PNLQTLFFGG NFIKWCTSPQ VPTNNSLTVL DLHDSSLQVV WDQGKCLHMF NHFSNVQGLN
     LSYNSIATLP DGIFDSLHSI QHIDLSFNAL TYLQPDTFPS ALKILDLSQN FLASPNPDAF
     QNVAFIDLFG NNFYCDCNLE GFLSWLNSTN VTFLIPKKHL NCTFPSPYKN VPLLDYFTVM
     EPCEEDNEKA MQELRLVLFI VCTVVVVGMM LGSLVYSHLR GHIFLLYKKV IGRVLEGPKP
     PAPQENLQYD AFVCYSDADY NWVEMALLKK LDSGFSEENL FRCCFEARDF MPGEDHLVNI
     RDAIWGSRKT LCVVSREFLK DGWCLEAFTL AQGRKLEELS NVLIMIVVGR VAHYQLMRHN
     AIRAFVQTRG YLVWPEDPQD LDWFYDRLTA QILKNDKPQK KPEENKEQPA EDNTVPMENI
     QVPAV
//