ID   A0A3B3Z9J3_9GOBI        Unreviewed;       830 AA.
AC   A0A3B3Z9J3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=G-protein coupled receptor family C group 6 member A {ECO:0000256|ARBA:ARBA00039774};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000001248.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000001248.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B3Z9J3; -.
DR   STRING; 409849.ENSPMGP00000001248; -.
DR   Ensembl; ENSPMGT00000001326.1; ENSPMGP00000001248.1; ENSPMGG00000001120.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.2300; -; 4.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF5; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        515..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        551..574
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        586..612
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        624..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        670..692
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        704..726
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        732..754
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          516..776
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   830 AA;  92967 MW;  E5CA7193F67AE514 CRC64;
     DIMIGGIFPL HEDVQRNTSF APKIPQCVRI LDRGVVRALA MVDAVQRANA APLLANANLT
     LGLWIRDSCS DVSTALRATE DFIREERHFV LQTNSLFIWR PVMALVGAGQ SEISIAVARQ
     LTLQMIPQIS YSSTASILSD KSRFPAFLRT IPNDEHQTGA MVSLISSFQW SWVGMVTTDG
     DYGLSALNNF LWQTADRQIC VAFKSVLPES VTNQNIHAAI RQTALTIYNN PKVKVIVSFA
     KPTIMESLFK ELKRQTLAAG DSLDAMRRVW IASDSWSSMD LKNVEELGHV VGFHFKRGNI
     EQFVNFLSRL EASEEGEGPE NSPELKSLRV RYLYADAVFS VQMAVLAIAY AAVEMCRHND
     CKTPEAIQPW QLLEALWMEE FETEGARYRF DQRGDINLGY DVSVWKVQAG GTVQETVAEY
     QPQNHSFSFT RGDAMNPLTN IVSRCSSSCA PGQFKKSAEG QHTCCYECIN CTENYYSNST
     DMDQCFSCNT DREWAPEGSV ACIPKEMLFF CWNNGFAIVL VAFSALGIVL ALLISALFYH
     QRHTPVVRAS GGPLSQVILY SLIVSFVSAM LFVGQPNSAQ CKARQVLYGI SFTVCVSCVL
     VKTLQILLAF QFNPAQQDVL RKLFQPYVIV SVCSALQVVT CICWLVLKSP FSYIINQNTT
     LLQDCHEGSY IAFGVMLGYI ALLAFICFVC AFKCRKLPQQ YNEARFITFS MLLYLMSWLL
     FIPIYVTTSG VYLPAVEMVV ILISNYGILS CHFFPKCYVI LLKKDKNTQS AFKKSLYEYS
     SKSTASFETS ESSENAVGLD WSTVEIKSVE VSVLNQDLKQ RQSLRRSFSV
//