ID A0A3B3ZBQ3_9GOBI Unreviewed; 762 AA.
AC A0A3B3ZBQ3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Short transient receptor potential channel 1 {ECO:0000256|ARBA:ARBA00013302};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000001993.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000001993.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Thought to form a receptor-activated non-selective calcium
CC permeant cation channel. Probably is operated by a phosphatidylinositol
CC second messenger system activated by receptor tyrosine kinases or G-
CC protein coupled receptors. Seems to be also activated by intracellular
CC calcium store depletion. {ECO:0000256|ARBA:ARBA00003698}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. TRPC1 sub-subfamily. {ECO:0000256|ARBA:ARBA00009944}.
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DR AlphaFoldDB; A0A3B3ZBQ3; -.
DR STRING; 409849.ENSPMGP00000001993; -.
DR Ensembl; ENSPMGT00000002122.1; ENSPMGP00000001993.1; ENSPMGG00000001798.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005457; TRPC1_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF56; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01642; TRPCHANNEL1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..762
FT /note="Short transient receptor potential channel 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017257013"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 157..219
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
SQ SEQUENCE 762 AA; 88245 MW; 9A46CA706FB14904 CRC64;
MHISICPYSL SVVMAALYQG ADASSPDKFL ALKDVREVKE ETTLDEKLYL LACEKGDYYM
VKKLLEENRH GELNINSVDV LGRDAVTIAI ENENLDILQL LLDHGCQKLM QRIQNPEYST
TMDVAPVILA AHRNNYEILT MLLKQDISLP RPHAVGCECT LCNAKNKKDS LRHSRFRLDI
YRCLASPSLI MLTEEDPILR AFELSADLKE LSLVEVEFRN DYEELAKQCK MFAKDLLAQA
RNSRELEVIL NHTSSEDHVD KRGLLEERMN LSRLKLAIKY NQKEFVAQSN CQQFLNTVWF
GETASYRRKH TCLKIATVLS VTVLWPLLSV CYLLVPRSRV GQIIHTPFVK FIIHSASYLT
FLLLLNLYSL VYNEGMKNTM GPALEMIDYL LILWIIGMVW SDVKRLWYDG LEDFLEESRN
QLSFVMNSLY LATFALRIVA HSKFKNVADT ERKNWDAFHP ILVAEGLFAF ANVLSYLRLF
YMYTTSSILG PLQISMGQML QEFGKFLGLF LLVLFSFTIG MTQLYGTEMK DREKNPPKDC
EGIFCEQQSN DAFHSFMGTC YALFWYIFSL AHVALFVTRI SYTEELRSFV GAMIIGTYNI
VVVIVLTKLL VAMLHKSFRQ IANHEDKEWK FARAKLWLSY FDDKCTLPPP FNILPSPKTV
CYLVTSLRKW ICSHTSKGKV KRQNSLKEVR NLKQKRDENY QKIMCCLVHR YLTSTRQKMQ
STDQATVENL NDLRQDLSKF RNEMRDLLGF RTSKYAMFYP RS
//