ID   A0A3B3ZGK2_9GOBI        Unreviewed;       916 AA.
AC   A0A3B3ZGK2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000003699.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000003699.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   AlphaFoldDB; A0A3B3ZGK2; -.
DR   Ensembl; ENSPMGT00000003935.1; ENSPMGP00000003699.1; ENSPMGG00000002537.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00365; LRR_SD22; 7.
DR   SMART; SM00369; LRR_TYP; 16.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 3.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        700..725
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        731..747
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          756..897
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   916 AA;  104904 MW;  13D37C5601F76E61 CRC64;
     KNIQMKTEKT STKNELTILL LLCDCVLIAK TYSVKNCYIY NDKAFCSKQK LSQIPTGIPP
     SVKSIDLSLN AFRKIQVLNF TNFPNLTTLN LKHNSISYIG KGTFSQLLSL NLLILNTNKI
     EHLEDDVFDG LFNLTELLLG FNRIQTVAPN AFRSLSSLKI LELSKNQLQS IGLLCGIIQH
     TPQLKNLQIR GNGIKTFKSN DLTNSSIGIT YLDLSENPLE TFEVSAAVFP MLSSLNLGSP
     SRKLNLTWAV QKQTVLENVT TLELTGVQLS SGSEWTRLFS SFNSSLTFLK LNCMKYKLRF
     LISVSCSIPT VSQLQLQSNK LTFISSSLFQ KLPSVPFATR NLRSLQKLDL SFNLIKTLEC
     QDFAQLTNLT QLNLQWNNLT ALNKCSFVTL SKLEILKLQG NLITKLGGAF TKNLPSLKSL
     LLNHNKLTAI GKHDFRGLYS LQNLSLSENQ IQTLDKSCFS GLKSLTYLQL QMNNLRKESI
     GNNCLRKLVK LRRLDLSSNH IKYQSSRLKV PPFMNLSNLE TLMFSVQRAR GKGLFPSNLL
     QGLTNLKTFT CNTNFIASLP YDSFTYTPHL TSLDISANEL LDITPQLFAP LRKLRHLRIN
     NIHAHSLHFL IDANLTELHE LEAKKNAFSV ISEDIVRSLP SLSVLGLQFN RFTCDCDNSW
     FVQWIKDNNQ TEVEDADNLR CNYPPQSMGK KLLHLNVQSC ILDVGFICFI STACTNILIL
     LVTFIYHFSR FQLIYAYYIF LAWLFDYKNR QKRAESQYDA FISYNTNDEA WVYRELVPRL
     EKEQGWRLCL HHRDFLPGKP IVENIADAIY GSRKTICVIS RRYLQSEWCS KEMQLASFRL
     FDEREDVLIL VFLEDIPSSH LSPYYRMKRV LKKRTYLRWP RPSEQQPLFW EKLRQALRSI
     STAEEDRLLL TVAQSS
//