ID   A0A3B3ZGQ3_9GOBI        Unreviewed;       914 AA.
AC   A0A3B3ZGQ3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000003749.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000003749.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   AlphaFoldDB; A0A3B3ZGQ3; -.
DR   Ensembl; ENSPMGT00000003992.1; ENSPMGP00000003749.1; ENSPMGG00000002537.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00365; LRR_SD22; 7.
DR   SMART; SM00369; LRR_TYP; 16.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 3.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..914
FT                   /note="TIR domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017316548"
FT   TRANSMEM        710..738
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          749..890
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   914 AA;  104843 MW;  DF593AFEB57C7BB3 CRC64;
     FSKFAIRELT ILLLLCDCVL IAKTYSVKNC YIYNDKAFCS KQKLSQIPTG IPPSVKSIDL
     SLNAFRKIQV LNFTNFPNLT TLNLKHNSIS YIGKGTFSQL LSLNLLILNT NKIEHLEDDV
     FDGLFNLTEL LLGFNRIQTV APNAFRSLSS LKILELSKNQ LQSIGLLCGI IQHTPQLKNL
     QIRGNGIKTF KSNDLTNSSI GITYLDLSEN PLETFEVSAA VFPMLSSLNL GSPSRKLNLT
     WAVQKQTVLE NVTTLELTGV QLSSGSEWTR LFSSFNSSLT FLKLNCMKYK LRFLISVSCS
     IPTVSQLQLQ SNKLTFISSS LFQKLPSVPF ATRNLRSLQK LDLSFNLIKT LECQDFAQLT
     NLTQLNLQWN NLTALNKCSF VTLSKLEILK LQGNLITKLG GAFTKNLPSL KSLLLNHNKL
     TAIGKHDFRG LYSLQNLSLS ENQIQTLDKS CFSGLKSLTY LQLQMNNLRK ESIGNNCLRK
     LVKLRRLDLS SNHIKYQSSR LKVPPFMNLS NLETLMFSVQ RARGKGLFPS NLLQGLTNLK
     TFTCNTNFIA SLPYDSFTYT PHLTSLDISA NELLDITPQL FAPLRKLRHL RINNIHAHSL
     HFLIDANLTE LHELEAKKNA FSVISEDIVR SLPSLSVLGL QFNRFTCDCD NSWFVQWIKD
     NNQTEVEDAD NLRCNYPPQS MGKKLLHLNV QSCILDVGFI CFISTACTNI LILLVTFIYH
     FSRFQLIYAY YIFLAWLFDY KNRQKRAESQ YDAFISYNTN DEAWVYRELV PRLEKEQGWR
     LCLHHRDFLP GKPIVENIAD AIYGSRKTIC VISRRYLQSE WCSKEMQLAS FRLFDEREDV
     LILVFLEDIP SSHLSPYYRM KRVLKKRTYL RWPRPSEQQP LFWEKLRQAL RSISTAEEDR
     LLLTRCPNVQ LVRK
//