ID   A0A3B3ZJ72_9GOBI        Unreviewed;       845 AA.
AC   A0A3B3ZJ72;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000004466.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000004466.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU003431};
CC   -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC       {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004451}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   AlphaFoldDB; A0A3B3ZJ72; -.
DR   STRING; 409849.ENSPMGP00000004466; -.
DR   Ensembl; ENSPMGT00000004742.1; ENSPMGP00000004466.1; ENSPMGG00000003774.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF458; GUANYLATE CYCLASE; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Vision {ECO:0000256|ARBA:ARBA00023305}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..845
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017296082"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          276..545
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          615..745
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   845 AA;  94913 MW;  326CE22BBEE5CE1A CRC64;
     MFVVCCVVCL LCVLLCVCCV FVVCVLCWHD LDNSEFDCWP LVQPDEFNMI QCGGLEMAWI
     VRPPETVKSG EVFSVTYSVT AHDHFYQWAV DNKIFTHSSI VDAQSARSFC ENLDCPSNWK
     DANGENCCIH HANIHSCPMT YMTESICGPW IPDDGKIFTH TISTTGKMTQ TNWTSKVVLF
     HPGLTSLIAH IRVGHMQVAL ESKSTVLPAV ICGDGVCEEA ELCRTCPADC GECPMSTGAK
     VGIALPLGIL CTCCAFLCTW LWYQKQKLLW DESWIIDYSK IEKGLEFFSV LSVPLPTFFL
     LFLFDGRTVA IKKIHTKTFS LSKTIRQEVK QVRELDHPNL CKFIGGCVEA PNVAIVTEYC
     PKGSLNDVLL NDEIPLNWGF RFSFAMDIAR GMSYLHQHRI CHGRLKSLNC VLDDRWVCKI
     TDFGLNTFRR HDGAEPVSFY QQRLMEVYLP PEFQSSSLEP TQPGDVFCYS IILLEIVTRS
     DPVPAEESNL ETSWCLPLPE LIRSKTDNSC PCPSDYVELI RRCRSNNPAQ RPTFEQIKKF
     VHRINPVKGS PVDMMMNLME KYSKHLEVLV AERTQDLMHE KQKTDRLLYS MLPRQVADDL
     RQGITTQAQS YASATVFFSD IVGFTQLSSS STPYQVVDLL NKLYTTFDDI IDNYDVYKVE
     TIGDAYMVVS GVPKENGILH ASEIASMALD LVSVCKSFRI PHKPNMQLQI RAGIHSGPVV
     AGIVGTKMPR YCLFGDTVNT ASRMESTSLA LKIQCSSSAF YLLEEVDGYV LECRGTLQVK
     GKGDMVTYWL EGKKSGLGRK EVNVEAKTTK LVTMDSGVVT TDTEAETEMY RSLPGTLNQD
     LLTME
//