ID   A0A3B3ZPP6_9GOBI        Unreviewed;       560 AA.
AC   A0A3B3ZPP6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000006648.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000006648.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3ZPP6; -.
DR   STRING; 409849.ENSPMGP00000006648; -.
DR   Ensembl; ENSPMGT00000007073.1; ENSPMGP00000006648.1; ENSPMGG00000005563.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR   PANTHER; PTHR14247:SF6; SH2 DOMAIN-CONTAINING PROTEIN 3C; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          298..533
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          16..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  63484 MW;  C9FDA8F3905BDCAB CRC64;
     MPLSFHRCAL QESLLTPEEP KIPESDCGRS NHLSPPLTQE HSQANKAKHA NKANKANELL
     MFPTPSTKQD MTSAANQDLN RDLNQDLNQD LNQDLNQDLN QDLNRDLNQD LNEDLNQDLN
     QDLNQDLNED LNQDLNRDLN QDLNEDLNQD LNQDLNQDLN QDPDQNMDRC LDLQDLNQST
     DKQQDPNLNQ DLYLCEDSKQ NSVQDLDQDL DQDSSGYTEL VPQSYVERLH IEHQGPDKLK
     AKNISFSVPE STSCFSPRVE VTSCFRPLTY QSALMSTENR PLEVGVLRKV KHLLAQVHPK
     MAALHITKAD CEVRHFSCVL HRIMGAQSGV ELLTLPHGQQ LRLDLLERFE TMALALAVQV
     LGCTGSLEER ASLVNRLILT ASELRSSVGN LFGFGAVMRA LQLPQVSRLD QTWVTLRQRH
     TEGAVLFEKT LRPFMKNLNE GRETCPLSGT CFPHVLPLLV LMERGLWDSD LGVDVLMFHL
     SAARTMAQLG NVYKTNATSK LQGLEPDSGL EQVFSTEFQM RLLWGHRGAS APQHLRYHKF
     YQVLTALSHK LEPPRTRTKK
//