ID A0A3B3ZVI9_9GOBI Unreviewed; 1465 AA.
AC A0A3B3ZVI9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000008732.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000008732.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR STRING; 409849.ENSPMGP00000008732; -.
DR Ensembl; ENSPMGT00000009292.1; ENSPMGP00000008732.1; ENSPMGG00000007240.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 827..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..94
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 106..195
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 203..285
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 292..382
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 387..483
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 485..578
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 580..666
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 917..1160
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1092..1163
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1197..1456
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1374..1447
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1465 AA; 165613 MW; E38DC5A6C86ED58F CRC64;
NTPPKFLRTP NDQTGVQGGV ASFICQATGD PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS
VLRIQPLRTP RDEAIYECVA SNSVGEISAT TRLTVLREDQ LPQGFPTIDM GPQLKVVERT
RTATMLCAAS GNPDPDISWF KDFLPVNTTN NNGRIKQLRS GALQIEQSEE SDQGKYECVA
TNNDGTRYSA PANLYVRVRR VPPRFSIPPT DNEIMPGGSV NITCVAVGSP MPYVKWMLGA
EDLTPEDDMP IGRNVLELTD VRQSANYTCV AMSTLGVIEA VAQITVKALP KAPGVPVVTE
RTATSITLTW DSGNPEPVTY YIIQHKSKYS DDNYKEIDGV ATTRYSVGGL SPYSDYEFRV
VAVNNIGRGP PSEIIEAKTA EQAPSTAPRQ VRGHMLSATT AVIHWDEPEE ANGQIMGYRV
YYTMDSTQHV NLWEKQIVRG SNFVTIQGLI PNKTYYIKVL AYTSVGDGPL SPDLQIIAKT
GVPSQPTDFK GEAKSETSIL LSWVAPAQTG QENQITGYEL MYRKRDDKEE KRISFEPTTT
YLLKDLKPFT TYTFRLAARS KHGVGAYTNE ISAETPQTLF AKNFHVKAAM KTSVLLTWEI
PDTYNPAQPF TILYDNGQSV EVDGKLTQKL ITGLQPETQY SFLLTNRGNS AGGLQHRVST
MTAPDVLRTK PYLIGKTNLD GMVTVEMPSV QTSERVRGYY VVVVPLRKQR TGKFFKPWEN
PDEMNWEELL KEINRTNREF RFRRQIEPKA YIAAYFKDLP KDFMLGDGKM YGEFENKQLQ
SGQEYIFFVV AVVEMSENIM YATSPYSDSV VSADIDPQPI IDEEEGLIWV VGPVLAVVFI
ICIVIAILLY KRKRAEAEAR KGSLPNSKEM PLHHPTDPVE LRRLNFQTPG MANHPPIPVM
DLADHLERLK ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS
AIDGIHGSDY INANYIDGYR KQNAYIATQG PLPETFGEFW RMIWEQRSAI VVMMTKLEER
SRVKCDQYWP TRGTETYGLI QVTLLDTVEL ATYCVRTFTL FKNGSSEKRE VRQFQFTAWP
DHGVPEHPTP FLAFLRRVKA CNPPDAGPMA VHCSAGVGRT GCFIVIDAML ERIKHEKTAD
IYGHVTLMRA QRNYMVQTED PLLEAVNCGT TEVPARNLYA YIQKLTQIEG GENVTGMELE
FKRLANTKAH TSRFISANLP CNKFKNRLVN IMPYESTRVC LQPIRGVEGS DYINASFIDG
YRQQKAYIAT QGPLAETTED FWRMLWEHNS TIVVMLTKLR EMGREKCHQY WPAERSARYQ
YFVVDPMAEY NMPQYILREF KVTDARDGQS RTVRQFQFTD WPEQGVPKSG EGFIDFIGQV
HKTKEQFGQD GPISVHCSAG VGRTGVFITL SIVLERMRYE GVVDIFQTVK MLRTQRPAMV
QTEDQYQFCY RAGLEYLGSF DHYAT
//
