ID   A0A3B3ZZE5_9GOBI        Unreviewed;       249 AA.
AC   A0A3B3ZZE5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE            EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000009774.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000009774.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-
CC         bisphosphate + H(+) + thyroxine sulfate; Xref=Rhea:RHEA:26422,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343,
CC         ChEBI:CHEBI:58910, ChEBI:CHEBI:305790; EC=2.8.2.n2;
CC         Evidence={ECO:0000256|ARBA:ARBA00036007};
CC   -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC       {ECO:0000256|ARBA:ARBA00005771, ECO:0000256|RuleBase:RU361155}.
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DR   AlphaFoldDB; A0A3B3ZZE5; -.
DR   Ensembl; ENSPMGT00000010422.1; ENSPMGP00000009774.1; ENSPMGG00000007844.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR11783:SF341; SULFOTRANSFERASE 6B1; 1.
DR   PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361155}.
FT   DOMAIN          47..241
FT                   /note="Sulfotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00685"
SQ   SEQUENCE   249 AA;  28311 MW;  3C454B05FCFD57C9 CRC64;
     IMQSRVEQAK GMRDEEKLYR YKGVLYPCIM CPEENLKALD SISARADDIM LVAYPKCGFN
     WMVGVLRQII AQASGVKEES RMPPLIEFFG PENVGNAPSP RFLGTHMHPD NIPATFYQNK
     SKMLVIFRNP KDTVVSYYHF CNNNPVLPSV KSWDSFFQDF MSGDVPWGSY FTHALAWEKK
     MDDPNVMIVT YEDLKQNLSE GVRQISTFFG FSLTEAQVEQ ISQGSTFSAM KERSANSHGN
     MGNVIFRKG
//