ID A0A3B4A8D1_9GOBI Unreviewed; 2557 AA.
AC A0A3B4A8D1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000013308.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000013308.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR STRING; 409849.ENSPMGP00000013308; -.
DR Ensembl; ENSPMGT00000014203.1; ENSPMGP00000013308.1; ENSPMGG00000010759.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 2157..2337
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 122..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2352..2393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2517..2550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..930
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1082..1108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2364..2380
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2517..2533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2557 AA; 291113 MW; D77B015BFF589D6D CRC64;
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTAKGL LYSSRISEEV NNLLVCRDEN
LVTQLVHSLN QVSTEHIELK DNLGNDEPEG DMPLLLQTLL SRNPKIFRDK SMQPSLIQQY
KVTQNQVHGS PASNYQQTSV PPSPSGCFTP QQSGSGARFI TKQNSPISSP YTPQSPDDYL
QYNPPSYSQH QQAQQVVTSP NLILSSAGMR NIHDNKVSGQ LSNNSNHNAQ VGSNDTYMNM
TQRLGNEANG SSTKGAAFSV GSPNSSCSPA AHEETTKRSR VIIQSPNDLP DKRVTSVEYK
KKHKERNKEE YEQIDKNALY DIVSSPMKDS SRLTLKLTRV RSSDTDHSGD MPAVENANHV
DTSVMKDTPS SRTTQESSQK LEAEEQANCH LPVVQHNAKD TGDEAETDAL SESERVEHES
SFEKERWNKD VQDKDKPLKK RKQDSYPQKP GVGGFSEAGD GQKGNRSSKM TPRKTVATNN
GTGRPALMVS IDLEQAGLGK AHPVVVLEPR EICEDHLKRL KSKSEDKGKV VENQTFIKQH
TDNSRKFDTH KNHQESQKEK TQNVPNDTSA ENNETETLRQ KHKANLETTL KEERNNSSHH
CNARIPDSKK ISNSTKINTS PETEKNRHKE KDKDRSKSVE KIRESNKDKL KNKEPSKDRR
DQNPSDERSK TREDKERSVN KDRDRGRGQP QEKEQDVVKD RSRNRAKELD TDKVQKKDQD
LDKDAKQKRG KETERDKRQE KQQDVEKSRN RNKDQEREKA KVQEKIQEPA KDVHHSKDKE
KTKDKTQTQD QAQEKEPKYI KGKERTKEKT QEKEPDHGKR TGNRRRSKDK ERDQDQDKTR
GNDRDRCRGR GDERERDGEK KQRLAQSEEN YNRQSGDQSA KPDCPKAKHD GSKRSAELNR
RSKTESTSSA NKEDRKGSGQ TADKHTVESK ASEFPSYLLG GTGSNLKNFV IPKLKRDATS
KCVDGLIEPR VVLDRVSLVK NLAKSSKPVI VLKRLSIDEV KRIIRDSRNV RSSKSGKLHI
SSTFELKYSP STSSVFSEML SNKRRHSVVS KKPKYVISDS EEDSEDPEDS DVVRKKSRKD
NDKSWKCDEK RGRSSSGRHR DRSPEDSDES SPPPNLTAVA RKLSKKEKQK NRKSYEPKQT
VEEMMDSSTF KRFTATLDSI LENLEDADFT ATENNRPVHL LKFHQLVKVL NILEKNIQDS
VKLSTLMHYS MDEEKLWRDL IMERVVRSAD ACLTALNIMT SPHMPKAVYI EDVIERVLQY
TKFHLLNTLY PQYDPVYRVD PHGGGVHSSK SKRAKCSSSK QKVVVKLYNK VCDVVGSMSE
LLEIQLLTDT TILQVSTLGI TPFFVENVSE LQLCAITLVT AVFSRYEKHR QLILEEIFTS
LCFHFNVTNM VSALVLQLIQ CVVQLPSERD GEEEHNKKVD KDVLITNAYE TAMRTAQNFL
SVFLKKCGSK QGEEDYRPLF ENFVHDLLST VNRPEWPAAE LLLSLLGRLL VHQFSNKQTE
MALRVASLDY LGTVASRLRK DAVTSKMDQK VIDRILRETP GNDEVQQLQK ALLDYIDDNV
ETDTSLLFAR NFYIAQWYRD VTSEVDKAMK SQNERDEDSK YYSKEVESTG DIMHKAETRK
KFLRKVIKTS PSQFSSLKMN SDVVDYEDCN LIVRYLASMR PFAQSFDIYL SQILRVLGES
AIAVRTKAMK CLSEVVAVDP SILGRTDMQR GVHCRLMDNS TSVREAAVEL LGRFVLSRPE
LIEQYYDMLI ERILDTGISV RKRVIKILRD ICLELPDFHK ITEMCVKMIR RVNDEEGIKK
LVNETFQKLW FTPTPNHDKE AMTRKILNIT DVVLACKDTG YDWFEQLLQN LLKSEENASY
KPAKKACIQL VDSLVEHILT YEESLAEDKG VSSGRLVSCI TTLYLFSKIR PQLMVKHAMT
MQPYLTTKLR TISWLFVTWL KSWTXXXTLE EDLMKLIIKY GMTVVQHCVS CLGAVVNKVT
HNYKFVWACF NRYYGALAKL KTQHQEDPTS PTLVNNKPTL LRSLFTVGAL CRHFDFDLEE
FKGATKVKIV IKDKVLELLM YFTTHQDEEV QIKALIGLGF QFIMYPELMF VQDVKVLYNN
NLSDESVSVS LKIQVLKNLQ TYLQEEDSRM QEADREWKKT AKQEDLKEMG DVSSGMSSSI
MQIYLKQVLE SFFHTQSTVR HYALNVITLT LGQGLIHPVQ CVPYLIAMGT DPEPTMKNKA
DNQLVEIDKK YSGFIHMKAV AGLKMSYQVQ QAIHGSKTAV VRGFRPDDRD SALCSHLYTM
VRGNRQHRRA FLISLLNLFD DSTKTEVNMV LFVADNLACF PYQTQDEPLF IMHHIDITLS
VSGSNLLQSF KEESSSSSSS SSEEEEEQVV RKKTKSADSD SDLDDEDAVL DRLPDNPGPL
LDFASASQGV LLLLMLKQHL KNLYGFSDSK IQKYSPTESA KVYDKAVNRK SSVHFNPRQT
LDFLKTDLAN TNLNYESKRN IVKQFLDFKL LMEHLDREEE EEDGEANANA KNKVITSLLK
GPKIQSNNHH TEAAPVETSD EESEDDSPPA VKLCFLI
//
