ID A0A3B4A9J3_9GOBI Unreviewed; 902 AA.
AC A0A3B4A9J3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000013385.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000013385.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; A0A3B4A9J3; -.
DR Ensembl; ENSPMGT00000014281.1; ENSPMGP00000013385.1; ENSPMGG00000010997.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 747..888
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 902 AA; 102459 MW; 05873BA53BCC0590 CRC64;
VIFLSVSPLL SLTLSFSLSL SHHSFSLSPP PLLLSLSTLS LSLPLSLINL SLSPLGRSDL
SGLGQLQTLH LGSNQISHIE SGTFLYSSAL TQLSLSENEL TVLTKDMFDG LSSVNFLHLG
INQIQFIPKD AFGPLTKLRE LHLPNNNLNQ ISDIVNILVS CPMLQVLNLR KNHLISFESD
RFPFPLNITD LDLGSNPLRK FTLHQNVFPH LKSLSLSPLR LDLEWDVSDD SFLQNLRTLD
LSSTDFAFET YKLIFQSVAS LEDLALRVVK TLLARGLLDF ACKIPSLRKL DLRANALSVL
SDSLLQQCSD VTHLDLSGNS LSVMSQSSLQ TLRRLSWLNL NTNALTQVPV AVRNMSTLTF
LSIAKNDLKK LECSDFLGLQ RLTELILTNN RLTDLNSCVF QDLLNLKILY IDQNLLYTFD
KQFSVTMRKL LVLNAKGTIG LLQKGVFQNM THLRVLAVGK GAFIDDGAFE GLTDLRYLSY
SPMFNTETGA GLESASGWRS LSQQFSNMPS LQILVITLPF SMCPVLPRDV LQGLNNLTSF
SSSRFFCKPH PEMFLFAPRL LNLEITDNEQ WQSPDPKILT PLRDLRKLDL SENHLQSLDL
ISEANLTKLE RLILTNNELK IIDEHVFDSL PSLKYLDLSG NLFVCNCSNA GFIQWVLSNK
QVYVARAFQY RCAYPLSHQG ELLLSFNVRS CWESEGLICF VTSSFLVLVT LLSSFVYHFL
RWQLVYGYFL FRARLYDRKK RREGSTHVYD AFVSYNVHDE EWVFHHLVPE LEERQGWKLC
LHHRDFEPGK AIIENITDAI YSSRKTLCVI SAQYLQSEWC SREIQMASFR LLDEQKDVLV
LLFLEELSSN QLSPFYRVRK MMRSHTYLSW TQARSHRGLF WERVRGALQS GNDPTNTLTA
NA
//
