ID A0A3B4ABZ0_9GOBI Unreviewed; 1127 AA.
AC A0A3B4ABZ0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Solute carrier family 12 member 2 {ECO:0008006|Google:ProtNLM};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000014597.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000014597.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3B4ABZ0; -.
DR STRING; 409849.ENSPMGP00000014597; -.
DR Ensembl; ENSPMGT00000015567.1; ENSPMGP00000014597.1; ENSPMGG00000011959.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF105; SOLUTE CARRIER FAMILY 12 MEMBER 2-LIKE; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 164..215
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 253..754
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 763..896
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 919..1127
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..47
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1127 AA; 122356 MW; EA769E6757536C99 CRC64;
MSGPKPSDSR FQVNVVSEAS ASGSAPVQPA GPAASPPAPP PLQVPSVPVY AAAPVPPAAA
PPAPVPAPPA SAPALVISPA PAPAPVYSPA PPVPVYSPAP AVPEAVRPPD ESRGRFRVVG
FSDPELGAPP DVFLEPDHVK SDSVSLHSTG TGHTHLSGVS HISDSHSNTY YMRTFGHNTI
DAVPNIDFYR QTAAPFGEKL TRPSLSELHD ELDKEPFEEG LANGDEPSAA EEAAALAAKE
AKGGMVKFGW VKGVLIRCML NIWGVMLFIR MSWIVGQAGI GLTIAIIFMA TLVTTITGLS
TSAIATNGFV RGGGAYYLIS RSLGPEFGGS IGLIFAFANA VAVAMYVVGF AETVVEMLND
VDALMTDELN DIRIVGTLTV ILLLGISVAG MEWEAKAQIV LLVILLAAIV NYFIGTFIPT
KSKEPKGFFG YNTAIFLENL GPDFRGDETF FSVFAIFFPA ATGILAGANI SGDLSDPQSA
IPKGTLLAIL ITGITYVAVA ISTGSCIVRD ATGDHNDTVS DTVNCTDAAC SLGFDFSICR
EGGCQYGLMN DFQVMSLVSA FGPLISAGIF SATLSSALAS LVSAPKVFQA LCKDNIYPGL
EVFAKGYGKN NEPLRGYVLT FCIGLAFILI AELNIIAPII SNFFLASYAL INFSVFHASL
ANSPGWRPSF KYYNMWVSLA GAVLCCGVMF IINWWAALVT LLIVLALYVY VGYKKPDVNW
GSSTQALIYN QALTHCLDLT GVPEHIKNFR PQCLVLAGFP NSRPALLHLV NSFTKNVGLM
ICGHVRTLSR RPNLKELSLE HGRCQRWLQK KNIKAFYSPV LADNLRHGAQ LLLQASGLGR
LRPNTLVMGF KNNWSDGDMR HTELYVNTIH DAFDLQFGVV LLRLQDGLDI SHIQGQVMCL
TVVFVLVCTS DSKPPLSLAD QRLLESSQIF KKKQGKGTID VWWLFDDGGL TLLIPYLLTN
RGKWGDCRIR VFMGGKINRI DHDRRAMAML LSRFRIDFSD IIVLGDINTK PKKHNKLSFK
ELIDPYRLRE DDMQQDEAER LKALEPWRIT DNELELYKAK TNRQIRLNEL LQEHSNTAKL
IVISMPLARK GTVSSALYMC WLETLSKDLP PVLLVRGNHQ SVLTFYS
//
