ID A0A3B4ACZ4_9GOBI Unreviewed; 1025 AA.
AC A0A3B4ACZ4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000014937.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000014937.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3B4ACZ4; -.
DR STRING; 409849.ENSPMGP00000014937; -.
DR Ensembl; ENSPMGT00000015922.1; ENSPMGP00000014937.1; ENSPMGG00000012234.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF105; SODIUM BICARBONATE COTRANSPORTER 3; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 431..453
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 460..479
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 518..541
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 548..566
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 647..665
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 685..703
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 733..752
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 773..797
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 833..852
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 859..878
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 917..941
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 87..353
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 402..911
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1025 AA; 115672 MW; F5B920A5B85259DB CRC64;
ESRRRHRHRG HKHHRKKKEK DEEGKGDGRD SPIDTPSQRV QFILGTEDDD LEHVPHDLFT
ELDELSFREG NATEWRETAR WLKFEEDVED GGERWSKPYV ATLSLHSLFE LRSCILNGTV
MLDMRASSIE EIADMVIDSM VASGQLKEDL RDKVREAMLK KHHHQNERKL SNRIPLVRSF
ADIGKKHSDP LLLEKNGPMF SPHSVPNNLD GNKAVERRPS KVGVSREGSS VDFSKVDMNF
MKKIPPGAEA SNVLVGEVDF LEKPITAFVR LSPAVLITGL TEVPVPTRFL FLLLGPHGKG
PTYHEIGRSM ATLMTDEIFH DVAYKAKDRT DILSGIDEFL DQVTVLPPGE WDPTIRIEPP
KNVPSQMKRK RPPQPNGTAS PSGDLEKSDD HQAGPELQRT GRIFGGLVLD IKRKVPFYWS
DIRDSLSLQC LASILFLYCA CMSPVITFGG LLGEATKNNI SAIESLFGAS LTGVAYSMFA
GQPLTILGST GPVLVFEKIL FKFCNDYGLS YLSLRTSIGL WTAFLCIVLV ATDASSLVCY
ITRFTEEAFA ALICIIFIYE ALEKLFHLGE HYPVNMHNDL DNLTSYTCQC APPINASAAI
KQVWNQSGYT EEDSIPWNSF SVSVCNQFHG EFVGPACGHH GPYIPDVLFW SVILFFTTFF
LSSFLKQFKT ERYFPTKVRS TISDFAVFIT IMIMVLVDYL MGIPSPKLNV PDRFEPTSKN
RGWLMDPLGD NPWWTLLVAV LPALLCTILI FMDQQITAVI INRKEHKLKK GCGYHLDLLI
VSVMLGVCSI MGLPWFVAAT VLSISHVNSL KVESECSAPG EQPKFLGIRE QRVTGFMIFV
LMGCSVFMTS VLKFIPMPVL YGVFLYMGVS SLKGIQFFDR IKLFGMPAKH QPDLIYLRYV
PLWKVHIFTL VQLSCLVLLW VIKASAAAVV FPMMVLALVF VRKLLDFIFT KRELSWLDDL
MPESKKKKED DKKKKAQEEL VLADDEDLGL KVAYENSNHL TIPVKTLTGK YVYHTHFILF
LFKML
//
