ID A0A3B4AD71_9GOBI Unreviewed; 827 AA.
AC A0A3B4AD71;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000014645.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000014645.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR AlphaFoldDB; A0A3B4AD71; -.
DR STRING; 409849.ENSPMGP00000014645; -.
DR Ensembl; ENSPMGT00000015616.1; ENSPMGP00000014645.1; ENSPMGG00000011996.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF7; NETRIN RECEPTOR UNC5C; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 271..296
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 58..133
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 427..561
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 827 AA; 91273 MW; 74463182311135C7 CRC64;
MVQEVLSLLH LCEQCHTCPP HTPLLSFVRR VLLCECFVCL FSPNLYFVIE TERSGRFCAQ
MKNPELQPLG HTQPHVEWLK DNDIIDPAED RNFYITVDHN LIIKQARLSD TGNYTCVAKN
IVAKRRSSTA TVIVYVNGGW STWTEWSACS SRCGRGFQKR TRSCTNPAPL NGGLPCVGQA
IQKLDCTTLC TVDGEWTDWS KWSACGTECT QWRRRECTNP APKNGGRDCE GLVLQSQNCT
DGLCMQSEFT ASANHKPPFP ASANHSASDA VALYVGVVIA VIMCLVISVI VALFIYRKTH
RDFDSVIIDS SALNGGFQSV IIKTARSADQ LTAPPDLTNA AALYRGPVYA LHDVSDKIPM
TNSPLLDPLP NLKIKVYNSS GLVTPVEDLG GDLSCKLSPK VTQSLLDHSD TMNLRNQTLA
RSRDPSCTAH GSFSNQGGHL IVPNSGVSLL VPAGAVPLGR VYEMYVTVHR KDSLRPPVED
IQTVLSPVVS CGPPGALLTR PVILTVHHCA DSVQQDWLIQ LKSQMAMGEW EDVVVVGEEN
FTTPCYVQMD HEACHLLTET LGTYCLAGQS LVPAAAKRLK LAVFGPVSCS TPDYHIRVYC
LDDNQDALKE VLQMETQMGG KLLDEPKSLR FKDSTHNLRL SIHDVPQPHW KSKLIAKYQE
IPFYQVWSGG QRSLHCTFTL ERLSSCSTDL SCKLCVRQVE GEGQIFSIAT TLQEEVQCID
TSLMDPANSI TSLQGPGAFR IPLSIRQKLC GSLDAPQTRG NDWRILAHKL HLDRYLNYFA
TKSSPTGVIL DLWEAQHFPD GDLNELAAVL EEMGRHDNSL GAVTMDH
//