ID   A0A3B4AE24_9GOBI        Unreviewed;       543 AA.
AC   A0A3B4AE24;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=NF-kappa-B essential modulator {ECO:0000256|ARBA:ARBA00040893};
DE   AltName: Full=IkB kinase-associated protein 1 {ECO:0000256|ARBA:ARBA00041660};
DE   AltName: Full=Inhibitor of nuclear factor kappa-B kinase subunit gamma {ECO:0000256|ARBA:ARBA00043239};
DE   AltName: Full=NF-kappa-B essential modifier {ECO:0000256|ARBA:ARBA00041525};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000015322.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000015322.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B4AE24; -.
DR   STRING; 409849.ENSPMGP00000015322; -.
DR   Ensembl; ENSPMGT00000016337.1; ENSPMGP00000015322.1; ENSPMGG00000012556.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR   CDD; cd09803; UBAN; 1.
DR   Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 2.
DR   Gene3D; 1.20.5.990; Nemo cc2-lz domain - 1d5 darpin complex; 1.
DR   InterPro; IPR032419; CC2-LZ_dom.
DR   InterPro; IPR021063; NEMO_N.
DR   InterPro; IPR034735; NEMO_ZF.
DR   PANTHER; PTHR31553; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR   PANTHER; PTHR31553:SF3; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR   Pfam; PF16516; CC2-LZ; 1.
DR   Pfam; PF11577; NEMO; 1.
DR   Pfam; PF18414; zf_C2H2_10; 1.
DR   PROSITE; PS51801; ZF_CCHC_NOA; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU01142}.
FT   DOMAIN          512..542
FT                   /note="CCHC NOA-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51801"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          99..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          144..188
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          244..271
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          297..331
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          375..458
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   543 AA;  62496 MW;  C1D9DA64ED405ACC CRC64;
     MVQPQPDGPM HWDMSAEDSG GALRVPPELA ANEVVTRLLC DNQQLREALR RSNLALRQRC
     EEMEGWQRKT KEEREFLSCR FQEARALVER LAQENHSLQS LVNAPSSGSG HRCSSSQTEE
     QRASNGPLEP PQVNTDRGST KDVLQFLKSH KEKLEEEMRD LKRKNEEMER VREEGDKEKE
     RMRRFIDQLR GKLALAQVKL QLKGYVKGIV LMHQAYIEWY RELEEKLDYL QKSSAQRDKT
     EALLKQKDKD CAQLAKDCEN LKAQVTSLLG ELNERQTWLD KSEHERKVLE EKLCSKQKAL
     QGAERELEQQ KKQYQLAMDK LLLQTQSLEQ ALKAERLVVT EEKKKLTQLQ HAYTCLFRDY
     DSKFKNEGGD LCSRLEEAER ALALKQDLID KLKEEVEQQK GSLETIPVLT AQAEIYKADF
     LAEREAREKL NQKKEELQDQ LNQALGEIER LKQDAKSRAR IEVMKLRHLD DFPPRAPHIP
     QAPGGFPPFH TAPPPSSFRG QGVAVGDQAS ASEDIPDLCC PKCKYQAPDM DTLQIHVMDC
     ITF
//