ID A0A3B4AEW2_9GOBI Unreviewed; 926 AA.
AC A0A3B4AEW2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000015230.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000015230.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR STRING; 409849.ENSPMGP00000015230; -.
DR Ensembl; ENSPMGT00000016238.1; ENSPMGP00000015230.1; ENSPMGG00000011867.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd13720; PBP2_iGluR_NMDA_Nr3; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 4.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF364; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 494..516
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 528..547
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 567..588
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 739..759
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 337..718
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 380..441
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 926 AA; 102592 MW; C6440A1BE7902373 CRC64;
MCASHAAGEE CLIFRHVALV FYANRVPGVL YNVSVKFKVY GRHFHLQMSA RVPPSTLGSL
LLAVLQGGEE ERDRSGWGGA AVVCAGWEEG GEGVLSHLQM HSGTNWHLWD IVDLTHITGD
GERRGEASEE TREDQREEEA LRILSSRLLR SQSPISSVLL LGSDPECLSS VLRAAQRLSP
TLPALQWIMG YPMSPDALHT LGGPLGLLAY GEVGRKPLSF YIRDALHLLS RAVTAATMVR
PDLALVQSMV SCYDKLSRPD RPSSGPYLAR YLSNTSFTGA TGLIQVEPSH SRVLSSQLFH
VWSLKRGALG QPAWVTRRGG AGGGDSVGXX XXVEGHRLRV VTLVEHPFVF TREVDEDGQC
PAGQMCLDPR TNRSDVINNL FNQLHNPNDV RKCCYGYCID LLEKLAEDMG FTFDLYIVGD
GKYGALSGAG CWRGMVGDLL NGTADMAVTS FSINSARSRV IDFTSPFYST SLGILVRSKD
TAAPIGAFMW PLHWSMWVGI FVTLHLTALF LTLYEWNSPF GMTPHGRNRL RVFSYSSALN
LCYAILFGRT VATKTPKCWT GRFLMNLWAI FCLLVLSSYT ANLAAVMVGE KTFEQVSGIH
DDKLQHPSLG FRFGTVRESS AEDYMKKSFP EMHDYMRHTH MTDPPLLDAF IMDKALLDYE
VSIDADCKLL TVGKPFAIEG YGIGLPQGSP LTRNVSEFVS RYKSDGFMDM LHDKWYKVVP
CGKRVFAVTE TLQMGIQHFS GLFVLLCMGV GGALLTLAGE HTFYHLILPR LRRANTLQYW
LHTSQVRYKQ EQEYTGERVL TTAICPNACA HTLALGHDVF IVTLPASSTR SLTRSARSCY
FYLTIVSVNQ DMNINNRQIR CLLSPRSLPL ALATGLIDSV AKCTLLANPA VRTGSGVTFN
SLIARSRISY EHEVEKTGFI LLFTTF
//
