ID   A0A3B4AFB7_9GOBI        Unreviewed;       285 AA.
AC   A0A3B4AFB7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Bcl-2 Bcl-2 homology region 1-3 domain-containing protein {ECO:0000259|SMART:SM00337};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000015758.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000015758.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family.
CC       {ECO:0000256|ARBA:ARBA00009458}.
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DR   AlphaFoldDB; A0A3B4AFB7; -.
DR   STRING; 409849.ENSPMGP00000015758; -.
DR   Ensembl; ENSPMGT00000016812.1; ENSPMGP00000015758.1; ENSPMGG00000012905.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd06845; Bcl-2_like; 1.
DR   Gene3D; 1.10.437.10; Blc2-like; 1.
DR   InterPro; IPR013281; Apop_reg_Mc1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR026298; Bcl-2_fam.
DR   InterPro; IPR002475; Bcl2-like.
DR   PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR   PANTHER; PTHR11256:SF46; INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   PRINTS; PR01866; APOPREGMCL1.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00337; BCL; 1.
DR   SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        266..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          147..247
FT                   /note="Bcl-2 Bcl-2 homology region 1-3"
FT                   /evidence="ECO:0000259|SMART:SM00337"
FT   REGION          35..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   285 AA;  31535 MW;  C4A53DCD5D139CC5 CRC64;
     MNIINSPKRT ALKLSTMGLF LPQNGLAEGD MHCGAADSSA QMPRPATMDT RKGNTASSGS
     PHPRPTALVM KNELLNKNTR EEDYENSEGS LPCTPEFHSD SEMELSSYSA EHEVLESDTR
     QLLSDFFKLF TGISQPKWKQ RPALSTMKGV VDKLLEKHRY AYNGMINKLA LDDRGDDVSF
     IGTVAKSIFE DGTTNWGRIA SLIAFGAVVC QYLKTKGRES CVERVGQEIS SYLLLDQRDW
     LVRNNAWDGF VDFFRVEDPE SAVRNTLMAV AGLAGIGATL AMLIR
//