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Database: UniProt
Entry: A0A3B4AGM4_9GOBI
LinkDB: A0A3B4AGM4_9GOBI
Original site: A0A3B4AGM4_9GOBI 
ID   A0A3B4AGM4_9GOBI        Unreviewed;       345 AA.
AC   A0A3B4AGM4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=TLC domain-containing protein {ECO:0000259|PROSITE:PS50922};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000016232.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000016232.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=octadecanoyl-CoA + sphinganine = CoA + H(+) + N-
CC         (octadecanoyl)-sphinganine; Xref=Rhea:RHEA:36547, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57817,
CC         ChEBI:CHEBI:67033; Evidence={ECO:0000256|ARBA:ARBA00024546};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36548;
CC         Evidence={ECO:0000256|ARBA:ARBA00024546};
CC   -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC       {ECO:0000256|ARBA:ARBA00004760}.
CC   -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B4AGM4; -.
DR   STRING; 409849.ENSPMGP00000016232; -.
DR   Ensembl; ENSPMGT00000017319.1; ENSPMGP00000016232.1; ENSPMGG00000013322.1.
DR   UniPathway; UPA00222; -.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0050291; F:sphingosine N-acyltransferase activity; IEA:InterPro.
DR   GO; GO:0046513; P:ceramide biosynthetic process; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR024578; Homez_homeobox_dom.
DR   InterPro; IPR016439; Lag1/Lac1-like.
DR   InterPro; IPR006634; TLC-dom.
DR   PANTHER; PTHR12560:SF62; CERAMIDE SYNTHASE 3A-RELATED; 1.
DR   PANTHER; PTHR12560; LONGEVITY ASSURANCE FACTOR 1 LAG1; 1.
DR   Pfam; PF11569; Homez; 1.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   PIRSF; PIRSF005225; LAG1_LAC1; 1.
DR   SMART; SM00724; TLC; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00205}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00205};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        37..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        177..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        261..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          128..329
FT                   /note="TLC"
FT                   /evidence="ECO:0000259|PROSITE:PS50922"
SQ   SEQUENCE   345 AA;  41259 MW;  61ED252713AC7AE6 CRC64;
     MLNSWRLFWW DRLWLPGNLT WADLEDKEGR VYAKASHLYA TIPFTVGFLL IRFIFERWIA
     TPLALMAGVK RRIRVQTEDN PILEHYYSRQ SPSQADLTGL CKKSGLSVRQ VERWFRRRRR
     MDQPGVLRKF TEACWRFFFY LLAFGGGILA VYDKEWFYDT KEVWTGFPKQ SMLDSQYWYY
     ILEMSFYCSL LLSVAFDIKR KDFREQIIHH CATLVLLSFS WCVNYIRVGT LVMLVHDASD
     VLLESAKLFN YAKWETTCKS LFVLFAIVFM LTRLVIFPFW LIHCTWVYPP HYYPPFFGYY
     FFNVMLLILQ ALHLFWAYLI LRMVHKFVFG KVRLSSITTT ATTIL
//
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