ID   A0A3B4AGS1_9GOBI        Unreviewed;       407 AA.
AC   A0A3B4AGS1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=MPN domain-containing protein {ECO:0000259|PROSITE:PS50249};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000016278.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000016278.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M67C family.
CC       {ECO:0000256|ARBA:ARBA00010981}.
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DR   AlphaFoldDB; A0A3B4AGS1; -.
DR   STRING; 409849.ENSPMGP00000016278; -.
DR   Ensembl; ENSPMGT00000017370.1; ENSPMGP00000016278.1; ENSPMGG00000013354.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   CDD; cd08066; MPN_AMSH_like; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR   InterPro; IPR015063; USP8_dimer.
DR   PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR   PANTHER; PTHR12947:SF7; AMSH-LIKE PROTEASE; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF08969; USP8_dimer; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR   SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          240..368
FT                   /note="MPN"
FT                   /evidence="ECO:0000259|PROSITE:PS50249"
FT   REGION          201..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  46834 MW;  02C6282CE02C8F38 CRC64;
     YSARCCALVM QRKLAAEPQY SDVSLPPVER VRALGRMGRS VQVEVDLSPH LYLRWGRDME
     RMAAAYHQEE QLENAYVLYN KFITLFVEKL PLHRDYHECS SSPEKVFIMK KLQEVAFPRR
     DELKKKLEEK YNREYAGYLN NKHQQASPLA VTPGALLLAD GSLGQGQWLE QERRRVDDLR
     RRQIESEQFI RFEEQLRRQE RANQREEGAG LQANLREEGA GPHESANQEE QQRLEGLRRV
     VLPRDLTLRF LRLAESNTNR GLETCGVLCG RLAREELVVT HVVVPKQTSG PDFCDMENVE
     ELFCFQDQQN LLTLGWIHTH PTQTAFLSSV DLHTHCSFQL MLPEAIAVVC APRHNDCAVF
     RLTGPGISAV SRCRLKGFHP HSRDPPLFSV CKHVLVRDCA VMLLDLR
//