ID   A0A3B4AIH3_9GOBI        Unreviewed;       849 AA.
AC   A0A3B4AIH3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000016409.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000016409.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; A0A3B4AIH3; -.
DR   STRING; 409849.ENSPMGP00000016409; -.
DR   Ensembl; ENSPMGT00000017518.1; ENSPMGP00000016409.1; ENSPMGG00000013473.1.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF22; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        409..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        454..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        548..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        578..601
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        644..667
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        779..802
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          94..128
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   849 AA;  97710 MW;  A4D61D56609BA6C2 CRC64;
     MNSLLRSEEM CLAQLFLQSG SAYDCISELG ELGLVEFRDL NPSVNAFQRK HVNEIKKCEE
     MERILSYLLR EIKKADISLP EGDVNPAAPL PKHVIAIMEQ LQRLEVELGE VTRNKEKLQK
     NLLELTEYTH MLRITRNFVQ KSSERESLQV QYEEFPFLEK ETMMDYSSMQ RLGAKLGFIS
     GLIHRVKIEA FERMLWRVCK GYTILSYAEL DEYLDDPDTG EPTKSVVFLI SYWGEQIGQK
     VKKICDCYHC HLYPYPSNNE ERNDVVEGLK TRIQDLHIVL HRTEEYLKQV LIRASESVYT
     WVLQIKKMKA IYYVLNQCSF DVTNKCLIAE VWCPVNDLPA LRRALEEGSR KSGATVPSFV
     NRIPTSDTPP SLIRTNKFTS GFQNIVDAYG VCSYREVNPA PFTIITFPFL FAVMFGDLGH
     GIIMALFAFW MVFYENDRKL KNTRNEIWNT FFEGRYIILM MGLFSVYTGF IYNDCFSKSL
     NIFGSKWNVS AMIEAKIWKR EDILGNRALT LDPNVTGVFT GPYPFGIDPI WNLATNRLTF
     LNSYKMKMSV ILGIIHMSFG VILSTFNHLH FRKSYNLYLV LLPELLFLLC LFGYLVFMIL
     YKWLAFSAKD SRHAPSILIH FINMFLMQGD ATQPLYAGQN GLQIFLLLIA VLSVPVLLMG
     KPLYLYWLSK GHHRIGAYRG YERVRHDSDE ELYLLRAHDM EEGSSHSEVS MSGEHQSEEF
     NFADEFLHQA IHTIEYCLGC ISNTASYLRL WALSLAHAQL SEVLWAMVMR VGLKMDTSLG
     VLFLVPVFGL FAVLTVSILL VMEGLSAFLH ALRLHWVEFQ NKFYSGSGVK FVPFSFSLMP
     SSFDNDGLL
//