ID A0A3B4ALM5_9GOBI Unreviewed; 649 AA.
AC A0A3B4ALM5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Homeobox domain-containing protein {ECO:0000259|PROSITE:PS50071};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000017301.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000017301.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR AlphaFoldDB; A0A3B4ALM5; -.
DR Ensembl; ENSPMGT00000018470.1; ENSPMGP00000017301.1; ENSPMGG00000014165.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR031701; SIX1_SD.
DR PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR PANTHER; PTHR10390:SF65; HOMEOBOX PROTEIN SIX4.3; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 213..264
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 215..265
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 21..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 68724 MW; 8AF37D3D55644F1B CRC64;
MIGQGRCETV ACADCAVWSS GSPGEGGERG GGTTAGKKVK SKMASLSLDS EEQSPKTKDE
HTPAHVKEEE DFGRSVASEK QSLQNSELSF STDQVSCLCE ALLQAGNVDR LWRFLSTIHP
SSELLRGNET LLKAQALVAF HREEFKELYA ILESHDFHPS NHGFLQDLYL KARYKEAERS
RGRSLGAVDK YRLRKKFPLP KTIWDGEETV YLLKEKSRNA LKECYKSNRY PSPDEKKNLA
KVTGLSLKQV SNWFKNRRQR DRTPSGTHSK SESDGNHSTE DEASAMDDVP EQLEEPSSII
SFSAVSGNTG GPLILNGSSG FLTAPQPILL NGNSLISGAG GGVLINGLNL GDSSTLPEVG
ITTVSISQHA TNQLSQQLSS QLVDQNGPIA AVGKIQVPQL LSISSPTQVF PTPKGAHAQL
VSVSLPQLVP VSSIQTSNTI SFPQVVPATP SLTVSSAGPP VQILASGPTA PTSVAPSVQL
LNSGIIQLPA TPPGNLLLSG SPFLSVQQGK LILTIPAGIQ LTGLSSKPEV SSVSSNGVGP
SVASQPLSMP SLTSSFTTSA FTTSQTPIHS TTALEHSLST PPQNALTPES MLTLCPTYSL
SGGESLLLGS PSPEQGMDTS SPLASSEDIE GESKILTQLQ SVPIEPLEY
//
