ID A0A3B4ANH7_9GOBI Unreviewed; 463 AA.
AC A0A3B4ANH7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Thyroid hormone receptor beta {ECO:0008006|Google:ProtNLM};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000018240.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000018240.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR AlphaFoldDB; A0A3B4ANH7; -.
DR STRING; 409849.ENSPMGP00000018240; -.
DR Ensembl; ENSPMGT00000019456.1; ENSPMGP00000018240.1; ENSPMGG00000004025.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06961; NR_DBD_TR; 1.
DR CDD; cd06935; NR_LBD_TR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001728; ThyrH_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF210; THYROID HORMONE RECEPTOR BETA; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00546; THYROIDHORMR.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..463
FT /note="Thyroid hormone receptor beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017385127"
FT DOMAIN 27..104
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 140..384
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 463 AA; 52632 MW; CE940184BC34EA1F CRC64;
MNSTSYIKIF LFVLLPLGYI PSYLDKDELC VVCGDKATGY HYRCITCEGC KGFFRRTIQK
NLNPTYACKF EGKCAIDKVT RNQCQECRFK KCIAVGMATD LVLDDSKRLA KRKLIEENRV
KRKKEELQKT VFDRLEPTQE EWELIRMVTE AHMATNAQGN HWKQKRKFLP DDIGHASMVN
PPEGNKVDIE AFSQFTKIIT PAITRVVDFA KKLPMFCELP CEDQIILLKG CCMEIMSLRA
AVRYDPESET LTLNGEMAVT RGQLKNGGLG VVSDAIFDLG VSLSSFNLDD SEVALLQAVI
LLSSDRPGLS SIDRIERCQE EFLLAFEHYI NYRKHKLAHF WPKLLMKVTD LRMIGACHAS
RFLHMKVECP NELFPPLFLE VSPSCPSHSL NQASPTCFYG PTFGPDQSRK LSRICSTLLL
DYCFISTDMW NKYIRNFKGA LCTFPMGVVS TEMSLVCLEF SAV
//
