ID A0A3B4APU5_9GOBI Unreviewed; 1162 AA.
AC A0A3B4APU5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000018624.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000018624.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3B4APU5; -.
DR STRING; 409849.ENSPMGP00000018624; -.
DR Ensembl; ENSPMGT00000019866.1; ENSPMGP00000018624.1; ENSPMGG00000015194.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:UniProt.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR CDD; cd15450; 7tmC_mGluR5; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000202; GPCR_3_mGluR5.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR019588; Metabotropic_Glu_rcpt_Homer-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF165; METABOTROPIC GLUTAMATE RECEPTOR 5A; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF10606; GluR_Homer-bdg; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01055; MTABOTROPC5R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SMART; SM01229; GluR_Homer-bdg; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1162
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017321558"
FT TRANSMEM 583..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 736..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 801..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 581..843
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 1107..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 129394 MW; 09A1584E284FCA0D CRC64;
MQTCCFVLLL CLVVLDNTVR VSAQSNERRV LAHMPGDIII GALFSVHHQP PADKVHERKC
GAVREQYGIQ RVEAMMHTLD RINADPYILP NISLGCEIRD SCWHSAVALE QSIEFIRDTL
VSNDEEDNAG RCTAEGGSLL FQGKKPIVGL IGPGSSSVAI QVQNLLQLFN IPQIAYSATS
MDLSDKSLYK YFMRVVPSDM QQARAMVDIV KRYNWSYVSA IHTEGNYGES GMEAFKDMAA
KEGLCIAHSD KIYSNAGEQS FDKLLQKLRG HLPKARVVAC FCEGMTVRGI LMAMRRQRLV
GEFLLVGSDG WADRYDVTKS YEREAAGGIT IKLKSAHVTW FDDYYLNLKP DNNYRNPWFP
EFWQHRFQCR LRGHPQENTM YNRTWRESLR QQYAQDTKMG FVINAIYSMA YGLHAMQQSL
CPGYKGLCEN MRPIDGGKLL DFLMKTNFTG VSGEVIHFDQ NGDSPGRYEI MNFKLVGENE
YAYIHVGSWD QGGLQMNDEE IWSNNSEIIR SLCSEPCQKG QIKVIRKGEV SCCWTCTPCK
ENEFVFDEYT CQACTLGSWP NTDLTGCEPI PVHYLHWGDP EPIAAVVFAC LGLLATLFVT
SVFIKFWDTP VVKSSSRELC YIILAGICLG YLCTFSLIAK PHIIYCYLQR LGIGLSPAMS
YSALVTKTNR IARILAGSKK KICTKKPRFM SACAQLIIAF ILILLQLGII VALLIIEPPQ
VIYDYPSIRE VHLICNLTTL GVVAPLGYNG LLILSCTFYA FKTRNVPANF NEAKYIAFTM
YTTCIIWLAF VPIYFGSNYK IITMCFSVSL SATVALCCMF VPKVYIMLAK PEKNVRSAFT
TSTVVRMHVG DAKKAAKVGK SSSSMANFFR RRASGQEISS NGKSVTWAQN ERSYRPNLWK
RMSFHVKKKD PIETNQTAII KPFSKANSSA DTGVIQDYEE SMEPQSFNCS PSQSPLLSQQ
GAKGRSFQEE DVEEALTAYI PDHSLRRVES QSSNLVDCDI SAIGVGDIGI GMISGHVQGI
TIMDQISCVV NRFTANISEL NTMMLPGGGA INSNSPLPMS GDTSQCPAQQ YITSKSTVTT
YAEVTAVPSF CENRSVDMVY LSGTGVRRGK DREDQAALTP PSPFRDSSLG SNSSSPPSMS
PPSDADYDQL LLRHYSQSSS SL
//
