ID A0A3B4AQY2_9GOBI Unreviewed; 2554 AA.
AC A0A3B4AQY2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000019587.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000019587.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR STRING; 409849.ENSPMGP00000019587; -.
DR Ensembl; ENSPMGT00000020877.1; ENSPMGP00000019587.1; ENSPMGG00000015890.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1532..2099
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2207..2514
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2522..2554
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 411..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2554 AA; 287983 MW; 14F9694AF20A231D CRC64;
MESGLEMSAM IPALQELASA SAGGYEEAVQ KPRQILCQFI DRILTDVDVV ALGLSKKSSS
EPACVMLLHF VQHIIKSSSL MFANPACHFL FSSPHTDFSK WVLVRMLRVA ASPDCEVIHD
RICDVLSLLL HTLRVRAPLI YGRLTKELIS LLQNLSNIIH DHLLTLAGQG HILGVHSRSQ
WPVTLNSLNI CNASSYLTPS PLVLPDPASL ESLTVVTIKI ITDSLRGVVS PRDLSVAWES
SCYLLSNGTI RLKKAAMVML RELVEMGDFP KLQSHNFFMA FVELLEVHTD LPSSDTELDK
PYDGELLKLT QCVFQSSTEF EPIYLSQLFE SVCSIGATQN KLGTEVQETV CHIFSFLLSD
ALVYENVATL RRQRVTEVCK TLAQTVGSKN QAQCDEGFLK AALKAETAVV MQESKEEEPP
AKKSKSTKSV KSKTEIDMRV HSEVWAVINA RLEELLNFVN SNSHEAENPE ILSAVQGLAL
ILHLATLCSS PTRYENKLNL GLKKESVKIK ISLVNSYATK VLNFASLLTV NSHSEDGLQR
RVCALLSLPW VIEHKSASAF RTSALPPWLS ALAQRLTFSP EVQIDCLSLL ALVRQGVCDS
WRALVFSNSL KSPEDSVRAA AVRAFPLLLH HLGSSHYNLI KSSLLRLEDS SVQVKQELSR
IVGHLSCIQS EVSELSDTNT SHCPSSISCH RICLSDKHKG YTGELLKASF VQPFLPLLQQ
QAPTFLEALP HLCQHVSLSS GDSDSKAVSC ALIGLIEDSD TDVRASFGQS VRFLLTEDGQ
ASEQNSLSEL LVAHLKEGFN NAKLKRDDDL RITLILTTGE IGRVSQGSLV SFSLLRLLHC
LLSKSSPVSV AAYTQIRALA SAKGLKLQTL FSQYKNPICQ FLVESLHSRH ASALRSTPDQ
SSELANQREL ALDILAQIAH AFDFPDLHRF LSRTLQVLLP YLAAKASSTG SALIRALANE
LKANRREILI NNFKYIFSHL VCSCTKEELE RAFHYLQSET EIELGSLLRQ DFQGLHNELL
LRIQRSSRHH NTRENGGSSA GEKDRKKMAL TSVMALMKLM GSKHISSVRV KMMTTLRTGL
RYREDFPLLC CQTWDCFVRS VEPSHLGPLL SHVIVALLPL IPIQPKQTAA IIQFLIIENR
EEVNDYLHEI YFLPDHPELK EIHTVLQNYK KLTASRSDLA EALQLSMRAV QHENVDVRIH
ALTSLRDMMH SKQEWLLRQI CASEAVEPVI SSLVAVLLRG CQDPSPEARL LCGECLGELG
AVDPGRLDLS QNHNNGDRNN FVSGVDDPNF AYDLLTELIR TFLAYADNVR AQDSAAYAIQ
ELLSIFGCRE GRTDTPGRRL WRRFPEQMQE ILEPHLSSRY KSSQKEVNWS KLKKPIYLSN
RGSKFSDWAA TWAGYLISKV RHELAGKVFS CCSFIVKHDY KVTIYLLPHI LLYMLLNCTP
EEQQEVTEEM LAVLMEGHGH GEGLIQENAS SLSQLSTQTV FSMLSHLTQW SRHVLYSKCK
QNGKKFNDRR PPHTSGEYQR VVAFLKGIPQ DVLAKASLRS KAYTRAVMHF EAYILENKEN
VQDHLTFLQT LYAAMHEPDG VRGVNALRRE GPSLREQILE HESIGLLRDA TACYDRAIQL
ESDQIGHYHG VMTSMLGLGQ LSTVITQVNG VLANRPQWKS DLNTYRVEAA WKLGKWDLLE
DYLESDCPSS TWGVRLGQLL LAANKQDNKT FHEKLKLVRK EQVVPLSAAS YECGTYQRGY
EYIVRLHMLS ELEHAFTDLQ KQKSSPKTPQ LPLHWSERLE MTQNSFRAKE PILALRRALL
SLRSESASKE LIGECWLQSA RVARKGGHHQ TAFNALLNAE NTHLAELVTE KAKWLGSKGD
VHQALIVLQK GVEQCFPEDQ VLTDPRSLQT KGKAMLLVGH FMEETANFES NAIMKVYKVH
SPRNNTSTYY RNIYHFYFYI QDVTNLLPEW EDGNFYLAKY YDKVMPMVTD NKMEKQGNLI
RYIVTYCGKA LQYGNQYIYQ AMPRMLSLWL DFGAKVCECE KAGRADRQMR QEMSKINSVM
SEICENLAPY QFLSAFSQLI SRVCHSSDEV FDVLMAIVAK VFLAYPQQAM WLMTAVSKSS
YPMRMNRCNQ ILKKAVFLKQ SLDKFIGDAN RLTDKLLELC NKPVDGNSTT LSISVHFKQL
KRLVEEPTFS QILIPLQSVL IPTLPSTGGA NPNHDAFPGH WAYLDGFEDS VEILASLQKP
KKISLKGSDG RSYTMMCKPK DDLRKDCRLM EFNCLINKCL RKDAESRRRE LHIRTYAVIP
LNEECGIIEW VNHTAGLRHI LTKLYKERGI HLSGKELRKL LLPKTAPLEE KLRIHKEVLC
ARHPPVFYEW FLRTFPDPTS WYSSRSAYCR STAVMSMVGY ILGLGDRHGE NILFDSFTGE
CVHVDFNCLF NKGETFDVPE VVPFRLTQNM VHAMGPMGTE GLFRQACEVT LRLMRDQREP
LMSVLKTFLH DPLVEWSKAK GLSKTQANET GEIVNEKAKT HVCEIKQRLQ GVIKSRNKVL
GLPLSIEGHV HYLIQEATDD KMLCQMYLGW GPYL
//