ID A0A3B4ASD9_9GOBI Unreviewed; 251 AA.
AC A0A3B4ASD9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Glial cell line-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00015922, ECO:0000256|PIRNR:PIRNR016238};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000020097.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000020097.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Neurotrophic factor that enhances survival and morphological
CC differentiation of dopaminergic neurons and increases their high-
CC affinity dopamine uptake. {ECO:0000256|PIRNR:PIRNR016238}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|PIRNR:PIRNR016238}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR016238}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000256|ARBA:ARBA00009832, ECO:0000256|PIRNR:PIRNR016238}.
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DR AlphaFoldDB; A0A3B4ASD9; -.
DR STRING; 409849.ENSPMGP00000020097; -.
DR Ensembl; ENSPMGT00000021417.1; ENSPMGP00000020097.1; ENSPMGG00000016272.1.
DR OrthoDB; 5362928at2759; -.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR016649; GDNF.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR PANTHER; PTHR12173:SF1; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF016238; GDNF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR016238-1};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR016238}; Secreted {ECO:0000256|PIRNR:PIRNR016238};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..251
FT /note="Glial cell line-derived neurotrophic factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017311850"
FT DOMAIN 129..251
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 29..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 158..219
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT DISULFID 185..248
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT DISULFID 189..250
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT DISULFID 218
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
SQ SEQUENCE 251 AA; 28394 MW; A076FAC1D40CB944 CRC64;
MKLWDVLATC LLLLSSVATR PLYSNARPAK RTYFPSSSDS VSISEEDSEE ANFQPQQHSL
RQIPMEDQNY MRGPYPNHLE DVMDFIEATI GRLRRSSEAG GNSRGRRERQ RGAANAGRDR
EGRSHSDRRR GRSRGRGGKG GRGDRNRDRT TAVQGRGCLL KEVHLNVTDL GLGYQTKEEL
IFRYCSGPCV DAETNYDKIL NNLTHNKKLD KDTPSRTCCR PIAFDDDLSF LDDNVVYHTL
KKHSARKCAC V
//
