ID   A0A3B4AT84_9GOBI        Unreviewed;       890 AA.
AC   A0A3B4AT84;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000020392.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000020392.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   AlphaFoldDB; A0A3B4AT84; -.
DR   STRING; 409849.ENSPMGP00000020392; -.
DR   Ensembl; ENSPMGT00000021724.1; ENSPMGP00000020392.1; ENSPMGG00000016482.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR   GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR   CDD; cd09769; Luminal_IRE1; 1.
DR   CDD; cd10422; RNase_Ire1; 1.
DR   CDD; cd13982; STKc_IRE1; 1.
DR   Gene3D; 1.20.1440.180; KEN domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR045133; IRE1/2-like.
DR   InterPro; IPR010513; KEN_dom.
DR   InterPro; IPR038357; KEN_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR13954; IRE1-RELATED; 1.
DR   PANTHER; PTHR13954:SF30; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF06479; Ribonuc_2-5A; 1.
DR   SMART; SM00564; PQQ; 4.
DR   SMART; SM00580; PUG; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS51392; KEN; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          496..756
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          759..887
FT                   /note="KEN"
FT                   /evidence="ECO:0000259|PROSITE:PS51392"
SQ   SEQUENCE   890 AA;  99794 MW;  8C7522A683D1121D CRC64;
     MTCPIICIFV NWVGTIPPST TFYCTKACTC CVYNCPAVSF HVFQLFRGPL LFRTVLFFYW
     LTHWSITPYP RPFAPIFSPP PLQLRPDVTG SAPTRKYGAV SRTVALLLWI FTAVTLPESL
     LFVSTLDGSL HAVSKQSGDI KWTLREGSYI MDTSLTNPND GSLYILGGKH KEGLVKLPFT
     IPELVQSAPC RSSDGILYTG KKLDMWFVVD PETGEKQTSL TTGSSESICP NTPLLYIGRT
     EYMVTMFDTK TQELRWNATY NDYSAPAYDE KQDYKMAHLV SSGDGLVVTV DRETGDVLWS
     QNYGSPVVGV YLYSGDSLRH APHLSLAMET LRFLTFSSAN ERADPYSSLK WSYQPTLYVG
     KMDSHLYAST SLVHHGVSLV PRGVTLARIE GPLTEEVTVR ERGECEITPS TDVRYPPGST
     TSPKNHWLLI GTQHTHCEIS GVLLKHKSFN GPIYHISSSS SCPLHLSSAQ FPLHLSFSTP
     LLLSAPSKVQ VGKISFSPSD VLGHGTAGTF VFRGRFDGRH VAVKRILPEC LEVAEREVQL
     LRESDTHPNV IRYFCTERDR LFTYIAIELC AATLQQYVEN PSAFPDLSPI CLLEQTMCGL
     SHLHSLNIVH RDLKPRNILL SGPSAVGRVR ALISDFGLCK KIQDGRCSFS LRSGIPGTEG
     WIAPEVLRDT PGNKPTAAVD VFSAGCVFYY VVSGGQHPFG DALRRQVNIL SGEYALTYFK
     EETNNDVIAR DLIEQMISPD PVVRPSTACV LKHPFFWTPE KQLLFFQDVS DRIEKEPSDS
     PIVVRLETAS RSVVRTNWRM HISVSLQTDL RRFRTYKGNS VRDLLRAMRN KKHHYHELPR
     EVQETLGELP EGFVSYFTCR FPRLLMHTHT ALGVCAHERL FQPYYLSPTT
//