ID   A0A3B4AW73_9GOBI        Unreviewed;      1819 AA.
AC   A0A3B4AW73;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000021378.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000021378.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC   -!- SIMILARITY: Belongs to the plexin family.
CC       {ECO:0000256|ARBA:ARBA00010297}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   STRING; 409849.ENSPMGP00000021378; -.
DR   Ensembl; ENSPMGT00000022776.1; ENSPMGP00000021378.1; ENSPMGG00000017304.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR   CDD; cd00603; IPT_PCSR; 1.
DR   CDD; cd12791; RasGAP_plexin_B3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR031148; Plexin.
DR   InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR   InterPro; IPR046800; Plexin_RBD.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR041019; TIG1_plexin.
DR   InterPro; IPR041362; TIG2_plexin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR22625; PLEXIN; 1.
DR   PANTHER; PTHR22625:SF70; PLEXIN-B3; 1.
DR   Pfam; PF08337; Plexin_cytopl; 1.
DR   Pfam; PF20170; Plexin_RBD; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 3.
DR   Pfam; PF18020; TIG_2; 1.
DR   Pfam; PF17960; TIG_plexin; 1.
DR   SMART; SM00429; IPT; 3.
DR   SMART; SM00423; PSI; 3.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF81296; E set domains; 3.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1..433
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
SQ   SEQUENCE   1819 AA;  201547 MW;  67BF7CA9E947A657 CRC64;
     TGALYVGGVD RLYQLTSDLR VTAHVSTGPQ LDSPDCLPPI VAKDCPSATR THNYNKLLLL
     EEVGPEGNGA ESGSLIVCGT LFQGICEKRS LSNITNLLYR PTNPVDTQYV AANDPRISTV
     AVIISPEGAG MRLMLVGRGY TKGPGDIPPI TTRRLSPVIP PRRMFSQEEE LGKLVVGSYS
     EYNNHFVKAF VHGKHVYFLF SRRDMWHRKE YRTYVSRLCI SDRSFYSYVE VPLFCEGGYN
     LAQGAWLGNH TGRPALFVVM SAGQASTPVA TSRSALCVYG MEQLDGMLRR AQEVCYTEAG
     RGSSGQEEAY IEYQVSSKCY KLPKASLVDY PCGGEHTPNP IASTVPVKAT PTFTCTTHLS
     AVATATEAGL TIAFLGDRQG TLHKVLVHEN SSGHRYSSVP VHPNSPVSAD LLLDQTQEHV
     YVLTHNRLSK VSVSSCEQRT DCGSCLSMSD PYCGWCVLQG RCTRKHQCER HLQPNHWLWS
     FGAADHCVRV ERLQPANQSR DTQTKVTLSV LELPSLMSSE SLSCEFGQLA PSPAHITGNT
     VTCQSPEPHL LEATPPGTDH MILPVAVKFG NVTITTGNMT FYDCGAVSHL NRTSQCLSCV
     SSVWGCNWCP LDQLCSHSSN CPHHHTILNH RDSEGPSSCP LVYALQSPAL VPMGLSTTVV
     LLGKNLDIYT DKADYMCVVE VKGVQFNLSA SVQKTDDHTH TFTCSPHQFE VSELQYSAAV
     YLRRGQRRID ASPGLTLQLY DCSAGQSDCS QCRAVPPEYG CVWCPGSPTP SCVFNQSCSS
     AASDTCPPPH ITQIVPVTGP LEGGVLITIT GSNLGMKFED VEGGVSVAGV DCVAKAEGYH
     ISTRVVCELQ PSEKPKRGPV LIRVGPSASG RSTQEFTYQD PQLLGLVPDK GPISGGTRLT
     IRGRQLLTGQ ASDLQAFVGQ QPCFIVEEVT DSQLVCQTGT SNRTGGASVS VFFGKAERMV
     PNGAFKYMDD PVVTRVEPGE SYQAGGRMLL VEGSNLDVVQ RPLVVVWVEP ETQREVRRKR
     RRQVSELCVP ESATQMSCPT PKVSPQFKVK GLWFQLDNVR DKKSKSFVYY PNPELYPLNR
     DAPDTPYRFK PGGVIAVEGQ HLTRAMSREE VRARLGDQEC EVKTLDDTHL YCEPPEAQPN
     SLDHNDLPTL KVLMGNLEVD LGLVQYDSDS PLPPVPLAAQ IGLGAGAAVI ILSVLVVILM
     YRRKSKQALR DYKKVLLQLE TLEINVGDQC RKEFTDLMTE MMDLSSDVGG PGVPLLDYKT
     YAERVFFPGQ QGAPLSRQLD LPESRRTTVE QGLQQLNNLL NNRLFLTRFI HTLEAQQGFS
     QRDRGYVASL LTMALHDKLE YFTEVMKSLL QDLVQQYVAK NPKLMLRRTE TVVEKMLTNW
     MSICLYSFLK DVAGEPLYML YRAIKYQVDK GPVDSVTGKA KRTLNDSHLL REDIEYSAMT
     LTVLVKNGVE VQHCPVKVLD LDTITQVKDK ILDQVYKGAP FSQRPAADSL DLEWRSGQAG
     HLTLSDDDVT AVVQGRWKRI NTLQHYKVPD GATVALIPRC SAGNGVNQVF QTGEKTPMLE
     GEEEEGLRLW HLVKSSEDPE IPKHRKSSMR ERERAKAIPE IYLTRLLSMK GTLQKFVDDV
     FVAILSTKRP PPIAVRFFFD FLDDMAEKHG IDDPETVHIW KTNSLPLRFW VNILKNPQFV
     LDVQVTDSID AVLSVIAQTF IDSCTTSEHK VGRDSPVNKL LYAREIPRYK QLVERYYSDI
     HSAASGCYQE MNSTLTELSG SFASEMNTLV ALHELYKYIN KYYDQVIMAL EEDSSGQKMQ
     LAYRLQQVAA LVENKVTDL
//