ID   A0A3B4AXX6_9GOBI        Unreviewed;       922 AA.
AC   A0A3B4AXX6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000022087.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000022087.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   AlphaFoldDB; A0A3B4AXX6; -.
DR   Ensembl; ENSPMGT00000023526.1; ENSPMGP00000022087.1; ENSPMGG00000017521.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00365; LRR_SD22; 6.
DR   SMART; SM00369; LRR_TYP; 10.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 4.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        711..729
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        736..753
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          764..905
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   922 AA;  105948 MW;  19AD0399BF84D1B8 CRC64;
     WTSVTKMFIT ARLNTASVMY FHDSSEVFCD SSELTTIPQG IPKTVTYLTA AANHIVTIRE
     SDFNGFTKLE TLVLAKNYIK HIENGAFSDL FALNKLNLMH NKLTKLTDNM FEGLTNLTVL
     VLKNNKIKSI SPLCFKPLGK LQKLDMSFNM LVNNSDVVNI VSHCPSLKVL DLMWSMFTIF
     ETDFFPFPLQ DLMVLYLGSM TLSKFRVHSN VFPQLESLTL LGNGPALEWD VSDKVFTNLK
     TFEIGFTELK TETYKTIFQS FDSLENIYFS NLGRILDKRM FDFVCEIPSL QKFGVFRKNI
     SVIGDTLLQS CSRLTDLKLT QNALTELSES SLRTMTRLTN LSIESNRLSI IPPTIRNMSS
     LIQLSFDSNQ ILKLQCSDFL NLQSLRKISL NYNRISTFKS CVFQDLQNLR ELYLENNFIS
     QLDGTISNSL PNLAVFNVSE NHLRSIEKHT FFNMSHLTVL NLKSKSATEI QSGGLEGLVG
     LKRLTFSLNY HSGSVFEGLQ QLERLVVFIS SDIEMTELSE QRTLHLEALQ ELTIQVDKSA
     CVYHALYILH GLKKLRVLSL DTICCLTPSN IFGETPNLIN LQITNCVEIS PKPELFHPIT
     DLHILNLSHN KMKNLDFLIK ANLTKLEKLI LANNDLAVIN ETVFEALPSL KYLDLSGNPF
     VCDCSNAWFI NWTIRNKQVQ VVNAYQYRCS SPPTEEGHFL LDFNVQLCWE FTGFLCFIST
     SALVLVTLLS SFTYHFLRWQ LVYGFYLLLA FLYDSKKKRQ GCPDIYDAFV SYNVHDEDWV
     YKELLPELEE VQGWRLCLHH RDFQPGKPII ENITDAIYSS RKTLCVISRR YLQSEWCSRE
     IQMASYRLFD EQKDVLILLF LEEISSNQLS PFYRMRKLVK SRTYLSWTQA QSHKGLFWEN
     VRRALECGNE PTDNHNPLTA NV
//