ID A0A3B4AZ59_9GOBI Unreviewed; 1189 AA.
AC A0A3B4AZ59;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Enhancer of mRNA-decapping protein 4 {ECO:0000256|ARBA:ARBA00015762};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000021769.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000021769.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the WD repeat EDC4 family.
CC {ECO:0000256|ARBA:ARBA00009639}.
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DR AlphaFoldDB; A0A3B4AZ59; -.
DR Ensembl; ENSPMGT00000023189.1; ENSPMGP00000021769.1; ENSPMGG00000017546.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR Gene3D; 6.10.140.270; -; 1.
DR Gene3D; 1.10.220.100; conserved c-terminal region of ge- 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045152; EDC4-like.
DR InterPro; IPR049404; EDC4_C.
DR InterPro; IPR044938; EDC4_C_sf.
DR InterPro; IPR032401; EDC4_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15598; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR PANTHER; PTHR15598:SF5; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR Pfam; PF21289; EDC4_C; 1.
DR Pfam; PF16529; Ge1_WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 88..407
FT /note="Enhancer of mRNA-decapping protein 4 WD40 repeat
FT region"
FT /evidence="ECO:0000259|Pfam:PF16529"
FT REPEAT 264..297
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1060..1179
FT /note="Enhancer of mRNA-decapping protein 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21289"
FT REGION 496..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1189 AA; 130398 MW; BEAA2214EECA0367 CRC64;
MASSSNIDIE DATQHLRDIL KLDRTGTAQS SDEQRKSSFN GELNGLLGAA GLLGRLSGDN
GSTCKPITSN NVEIVASQDS SINSKARGSN KVKIQPVAKY DWEHKYYYGR LIAVSNSFLA
YAIKANNHAM IRVLSVGFTE RALLKGFTGA VTDLAFAHLD SSLLGCVDEA GNLVVWQLTC
TPSKIDEVVV HIRRPEDTPL NPHRRLIWCP FILDDNEENQ DDISQTLALL HEDRAEVWDL
EALRTNYSAW PIDASDVREG LITVKGHTQR VSEGALSPDG TVLATASHDG YIKFWQIYIE
GAQDKPCLHE LRPHGGQPLS CLLFCDNHKR QDPVPFWRFL ITGADQNQEL KMWCTVSWTC
LQTIFSPDPY NSTVLPSLKA SLDLSAEYLI LTDVQRKVLY VMELQQDLEK GKASFTAVSE
FLLTHPVLSF GVRDVTQSRL RHTEVLPAEE EGESLTTGTQ GAAESKSGIQ IKLYCVHTSL
QDVQILFQPN VGSSPADFLP HSDSQDGFFS DHLTDQSSDK DSGSGSQTDL SKIPSLPAPA
DFLTNSGAKL MTPDAFMTPS TSVPASPGSS ASSLTIVTAI SSNSDSTNAL DDVSQSPNRV
ENSSSSLGLS ASCSSPRAAS ALLPALDGIQ LPLELGGAEG PVSGSSEAEN RLSNTPSLLE
TALSQENPGV CAGASDGTVG HTPWPAAPDI TRETRNSLRD NGIVDDPDDE VASLASSSGN
CASRSSHRMQ VKEWKGSPRG SPKLKRKTKK EDEVQDELLI LLRNQQKELT DLRGQIEAMK
CSIMSQVEHA LSSYQEQEEC RMERLLVESQ SQQLQEHLSQ HLSQTLSSTL TNRMDRVLRE
EMKKTVPQIS KSLEPVSGQM NNAIAAKLTA VEVTLKDNVT KVVKSKNTTD AIGRAAAEAM
QGPIQAAYKD AFQTVVLPVF ERGCQSMFQQ INDSFKQGTQ EIQQLESHVK NRKQREQDVR
DPMIGQLQQM IDSFQNSTEQ LSNSITANVR AEVQHQVQMM VGLQESILSH VQRIVKGEVS
LAMKEQQAVV TSSIMQAMRS AAGTPVPTAH LDYQTQQANI LQLLQQGQLN QAFQQALSAT
DLNLVLYVCE TIDSQQVFGQ HPCPLSQPVL LSLIQQLSSN LSTRSELKIY LEDAVMNLDH
SDPLTRDHMA SVLAQVRPKL FSYLQQDPHS ALSKRARRLM MMLQGLVNH
//
