ID A0A3B4AZX0_9GOBI Unreviewed; 363 AA.
AC A0A3B4AZX0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Growth/differentiation factor 8 {ECO:0000256|ARBA:ARBA00023852, ECO:0000256|RuleBase:RU369049};
DE Short=GDF-8 {ECO:0000256|RuleBase:RU369049};
DE AltName: Full=Myostatin {ECO:0000256|ARBA:ARBA00031866, ECO:0000256|RuleBase:RU369049};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000022837.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000022837.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Acts specifically as a negative regulator of skeletal muscle
CC growth. {ECO:0000256|RuleBase:RU369049}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|RuleBase:RU369049}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU369049}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3B4AZX0; -.
DR Ensembl; ENSPMGT00000024326.1; ENSPMGP00000022837.1; ENSPMGG00000016611.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF150; GROWTH_DIFFERENTIATION FACTOR 8; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU369049};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU369049};
KW Disulfide bond {ECO:0000256|RuleBase:RU369049};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU369049};
KW Signal {ECO:0000256|RuleBase:RU369049, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..363
FT /note="Growth/differentiation factor 8"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017325030"
FT DOMAIN 251..363
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 363 AA; 41254 MW; 9B098085958C147F CRC64;
MHLSLPVSLL LVLLVWGGWC AGLNGTSPPT LEPVDQCSPC DFREHSKLLR LQSIKSQILS
ILRLERAPNI SRDMIRTLLP KAPPLTQLLD QYDPRVEEEE RASTETIITM YTEISTVEIN
QLFTCCLFSL SPKIQPRNIL SAQLWVHLRP PHEVSSVFLQ ISHLRPGREG NSTRVRVRSL
KLDIDTGAGS WQSVDIKSLL QVWLRQPENN YGIEINAFDS QGEDLAVKSA EPGEEGLQPF
IEVKILDNPK RSRRDVGLNC DEKSSETRCC RYPLTVDFEE FGWDWIIAPK RYRANYCSGE
CEFMHHQQYP HAHLVIKANP RGTAGPCCTP TKMSPINMLY FNRKEQIIYG KIPSMVVDHC
GCS
//
