ID   A0A3B4B0Y3_9GOBI        Unreviewed;       426 AA.
AC   A0A3B4B0Y3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=MPN domain-containing protein {ECO:0000259|PROSITE:PS50249};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000022359.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000022359.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M67C family.
CC       {ECO:0000256|ARBA:ARBA00010981}.
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DR   AlphaFoldDB; A0A3B4B0Y3; -.
DR   STRING; 409849.ENSPMGP00000022359; -.
DR   Ensembl; ENSPMGT00000023810.1; ENSPMGP00000022359.1; ENSPMGG00000018067.1.
DR   OrthoDB; 5490729at2759; -.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   CDD; cd08066; MPN_AMSH_like; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR   InterPro; IPR015063; USP8_dimer.
DR   PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR   PANTHER; PTHR12947:SF8; STAM-BINDING PROTEIN; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF08969; USP8_dimer; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR   SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          259..390
FT                   /note="MPN"
FT                   /evidence="ECO:0000259|PROSITE:PS50249"
FT   REGION          203..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          111..145
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        212..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   426 AA;  48460 MW;  6A9BEA07320EDAFF CRC64;
     MGDPSDVSLT PEERVRALTK KGSSVEVSDD VPPRRYFRSG MELIRMAHVY TEEGNIEHAF
     ILYNKYITLF IEKLPKHREY KTANIPEKKD TLKKLKDIAF PQAEILKKAL LKRFELEYSN
     YLLKKKEEEE ALVQEQSRQR ALDAERVRVA DMLRRQREQE QFSAFEEMIR RQDLEKERHK
     VLLEFATPVT PVPDTPLLPG IMGPPALAPS APASINNPQH QHSAVSSPTP VPPAFDRSLK
     PGSLSHSGSN TMVDALRQLF IPSELCRRFL QLAEANTIRA VETCGILCGK LTRNAFTVTH
     VIVPKQCGGP DYCDTENEEE LFLIQDQYDL ITLGWIHTHP TQTAFLSSVD LHTHCSYQMM
     LPEAIAIVCS PKFNEIGYFR LTEQGTQEIS ACRQKGFHPH SKEPPMFTHA GHVNIVEDTV
     SMMDLR
//