ID   A0A3B4B3D9_9GOBI        Unreviewed;       445 AA.
AC   A0A3B4B3D9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Beclin-1 {ECO:0000256|ARBA:ARBA00018490};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000023515.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000023515.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome
CC       {ECO:0000256|ARBA:ARBA00004419}. Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC       membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Mitochondrion membrane
CC       {ECO:0000256|ARBA:ARBA00004318}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004318}.
CC   -!- SIMILARITY: Belongs to the beclin family.
CC       {ECO:0000256|ARBA:ARBA00005965}.
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DR   AlphaFoldDB; A0A3B4B3D9; -.
DR   STRING; 409849.ENSPMGP00000023515; -.
DR   Ensembl; ENSPMGT00000025050.1; ENSPMGP00000023515.1; ENSPMGG00000019013.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.250.3110; -; 1.
DR   Gene3D; 1.10.418.40; Autophagy protein 6/Beclin 1; 1.
DR   InterPro; IPR007243; Atg6/Beclin.
DR   InterPro; IPR038274; Atg6/Beclin_C_sf.
DR   InterPro; IPR041691; Atg6/beclin_CC.
DR   InterPro; IPR040455; Atg6_BARA.
DR   InterPro; IPR029318; BH3_dom.
DR   PANTHER; PTHR12768; BECLIN 1; 1.
DR   PANTHER; PTHR12768:SF4; BECLIN-1; 1.
DR   Pfam; PF04111; APG6; 1.
DR   Pfam; PF17675; APG6_N; 1.
DR   Pfam; PF15285; BH3; 1.
PE   3: Inferred from homology;
KW   Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128}.
FT   DOMAIN          100..124
FT                   /note="Beclin-1 BH3"
FT                   /evidence="ECO:0000259|Pfam:PF15285"
FT   DOMAIN          130..256
FT                   /note="Atg6/beclin coiled-coil"
FT                   /evidence="ECO:0000259|Pfam:PF17675"
FT   DOMAIN          259..439
FT                   /note="Atg6 BARA"
FT                   /evidence="ECO:0000259|Pfam:PF04111"
FT   COILED          165..213
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   445 AA;  50927 MW;  E89603D5156F8F0C CRC64;
     MEGSKSSSTT MQVSFVCQRC CQPLKLDTSF NVLDRVTIQE LIAPLVTVTP SKQPESSEGG
     ETETFVENKQ DGVSRKYIPP ARMMSTESAN SFTLIGDASD GGTMENLSRR LKVTGDLFDI
     MSGQTDVDHP LCEECTDTLL DHLDTQLNIT ENECQNYKQC LELLSQLEVE QEETLLAELQ
     QLKEEEDSLI QELEAVEEQR AAVAQDLAQS RVQSQQLDTE ELQYQKEYSE FKRQQLELDD
     ELKSVDNQMR YCQIQLDRLK KTNVFNATFH IWHSGQFGTI NNFRLGRLPS VPVEWNEINA
     AWGQTVLLLH ALANKMGLRF QRYRLVPYGN HSYLESLTDK SKELPLYCSG GLRFFWDNKF
     DHAMVAFLDC VQQFKEEVEK GDTGFCLPYR MDVDKGKIED TGGSGGSYSI KTQFNSEEQW
     TKALKFMLTN LKWGLAWVTS QFYNR
//