ID A0A3B4B3R4_9GOBI Unreviewed; 368 AA.
AC A0A3B4B3R4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF {ECO:0000256|PIRNR:PIRNR037866};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000023645.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000023645.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Scaffold protein that connects plasma membrane proteins with
CC members of the ezrin/moesin/radixin family and thereby helps to link
CC them to the actin cytoskeleton and to regulate their surface
CC expression. {ECO:0000256|PIRNR:PIRNR037866}.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus
CC {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184,
CC ECO:0000256|PIRNR:PIRNR037866}.
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DR AlphaFoldDB; A0A3B4B3R4; -.
DR Ensembl; ENSPMGT00000025192.1; ENSPMGP00000023645.1; ENSPMGG00000019114.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 2.
DR InterPro; IPR015098; EBP50_C.
DR InterPro; IPR017300; NHERF-1/NHERF-2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14191:SF7; NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF1; 1.
DR PANTHER; PTHR14191; PDZ DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF09007; EBP50_C; 1.
DR Pfam; PF00595; PDZ; 2.
DR PIRSF; PIRSF037866; EBP50; 1.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR PROSITE; PS50106; PDZ; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Membrane {ECO:0000256|PIRNR:PIRNR037866}.
FT DOMAIN 8..88
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 154..234
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 109..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 368 AA; 39895 MW; CF9114878B3A73FE CRC64;
MSNLRPRRCV LEKCPDGYGF HLHGEKGKTG QFIRLVEPNT PAEAAGLRAG DRLAFVNGES
VEGESHAQVV ARIRASPVHL ELIVVDHETL ELLKRHNLQC QKEYVTEGIP IPGSSSGGGD
SDAEGSETRS SANGSFNSVL LVLQEEKSGP RPRLCHLKKG PGGYGFNLHS DKSRPGQFIR
AVDDDSAAQR AGLKPNDKII QVNGLSMVGK QHSDVVAAIK ASGDDVRLLV VDLEADRYFS
QCNVLPSEEH LTGPLPEPRA EQPSDEEQVQ NPHTAPSLSS LSSSILRPSL PLSTSLYPDL
LSSLLFLLPL SPLSPSLSPL DPQEEPASDS LGLGLSVAQA RERAHQKRMA KNAPRMDWNK
RKEVFSNL
//
