ID   A0A3B4B5Z1_9GOBI        Unreviewed;       429 AA.
AC   A0A3B4B5Z1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Growth/differentiation factor 10 {ECO:0000256|ARBA:ARBA00040122};
DE   AltName: Full=Bone morphogenetic protein 3B {ECO:0000256|ARBA:ARBA00042879};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000025082.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000025082.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   AlphaFoldDB; A0A3B4B5Z1; -.
DR   Ensembl; ENSPMGT00000026720.1; ENSPMGP00000025082.1; ENSPMGG00000020254.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13763; TGF_beta_BMP3_like; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF145; GROWTH_DIFFERENTIATION FACTOR 10; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   PRINTS; PR00669; INHIBINA.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..429
FT                   /note="Growth/differentiation factor 10"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017386803"
FT   DOMAIN          314..429
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          247..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..297
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..328
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   429 AA;  48149 MW;  F82234848F023B4E CRC64;
     MIFAHLFLVW GSFLGAVAHR AGKVGSGGAQ ERRGAHSPLD YFSDNMGQED TLSQHMFKLY
     EKSSRESRLR EGNTVRSFRV TPGELTVYRL NLTTLQDSEV ILSVTFHFLL ERRPPHKPWF
     CKRFKSSLCH SPAVHSAMSV SLLLRSVSSG SEVDSGSIGS LLGNVTFHPH RRGVWQMKDL
     TQVIKEARDR GHLLLSLEMD VGSQYHRSPA EVLSTGSLPY FLIYADDQAL EEPNSVAASL
     QRYDPAIETG DPSLSSQHKP NTAPERVRRV MKQSKDGEFP GRRDERRNSD KKHKGSSTQE
     SPLLSFDEKT MRKARRRQSS ESQERTCSRR NLRVDFADIG WSEWVIAPKA FEAYYCAGTC
     GFPIPKVTRP SNHATIQSIV RAVGIIPGIP EPCCVPEKMS PLPVLYQDEA NNPVLKVYPN
     MSVQSCSCR
//