ID   A0A3B4B731_9GOBI        Unreviewed;       726 AA.
AC   A0A3B4B731;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Phosphofructokinase domain-containing protein {ECO:0000259|Pfam:PF00365};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000024351.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000024351.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-
CC         bisphosphate + H(+); Xref=Rhea:RHEA:16109, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:57634,
CC         ChEBI:CHEBI:456216; EC=2.7.1.11;
CC         Evidence={ECO:0000256|ARBA:ARBA00000432};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004679}.
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DR   AlphaFoldDB; A0A3B4B731; -.
DR   Ensembl; ENSPMGT00000025946.1; ENSPMGP00000024351.1; ENSPMGG00000019664.1.
DR   UniPathway; UPA00109; UER00182.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.450; -; 3.
DR   Gene3D; 3.40.50.460; Phosphofructokinase domain; 2.
DR   InterPro; IPR022953; ATP_PFK.
DR   InterPro; IPR015912; Phosphofructokinase_CS.
DR   InterPro; IPR000023; Phosphofructokinase_dom.
DR   InterPro; IPR035966; PKF_sf.
DR   PANTHER; PTHR13697:SF14; ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE; 1.
DR   PANTHER; PTHR13697; PHOSPHOFRUCTOKINASE; 1.
DR   Pfam; PF00365; PFK; 3.
DR   PRINTS; PR00476; PHFRCTKINASE.
DR   SUPFAM; SSF53784; Phosphofructokinase; 2.
DR   PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 2.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          12..299
FT                   /note="Phosphofructokinase"
FT                   /evidence="ECO:0000259|Pfam:PF00365"
FT   DOMAIN          374..420
FT                   /note="Phosphofructokinase"
FT                   /evidence="ECO:0000259|Pfam:PF00365"
FT   DOMAIN          426..634
FT                   /note="Phosphofructokinase"
FT                   /evidence="ECO:0000259|Pfam:PF00365"
SQ   SEQUENCE   726 AA;  79212 MW;  D01249D6495A541B CRC64;
     EKLKMTGAGR AMAVLTSGGD AQMNAAVRAV TRMGIYVGAK VYLIHEGYQG LVDGGDNIKL
     AHWHSVTNII QLGGTVIGSA RCKAFTTREG RLAAAFNLVK RGITNLCVCG GDGSLTGANI
     FRSEWSGLLQ ELVEKRIAET MAKQFSHLNI VGLVGSIDND FCGTDMTIGA DSALHRIMEI
     VDAIMTTAQY LALVSALAAG AEWLFIPEVP PQEGWEDRMC ARLEAQSRTG SRLNIVIVAE
     GAIDRNGKPI SSTYIKDLVV KRLGYDTRVT VLGHVQRGGT PSAFDRILSS KLGVEAVVAL
     MEAAPDTPAC VIGLSGNHAV RLPLMECVEM TKLVQQSMNE KRFDEAVKLR GSFENNWNIY
     KLLAFQKPAT DYSLAIVNVG APAPGMNAAV RSAVRLAIAH GHKVYAFNNG FQGLADGEVS
     LPSKCLDKIV STLNKYRITA LLVIGGFEGY HGVLELFEAR RHFEELCIPM CIIPATISNN
     VPGTDFSVGA DTAVNAAMEG CDKIKQSASG TKRRVFVVET MGGFCGYLAT STGLAVGADA
     VYIYEDPFTI HDLKTNVEHL AEKMKKDIQR GLVLNEYCHE HYTTDFIHKL YSAEGKGIFD
     CRVNVLGHLQ QGGAPSPFDR NFGTKMGVKA VQWLSQKMTE NYRQRVFANS PNTACVLGLN
     RKVVAFTPVA ELKEITDFHR VPKDQWWFHM RPLLKMLAKY QTSFSEYVPG SLKHVTQRSL
     SVDTGF
//