ID   A0A3B4B826_9GOBI        Unreviewed;       575 AA.
AC   A0A3B4B826;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000024694.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000024694.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   AlphaFoldDB; A0A3B4B826; -.
DR   Ensembl; ENSPMGT00000026315.1; ENSPMGP00000024694.1; ENSPMGG00000019976.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00054; EGF_CA; 2.
DR   Gene3D; 1.20.5.30; -; 1.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR036337; Matrilin_cc_sf.
DR   InterPro; IPR019466; Matrilin_coiled-coil_trimer.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR   PANTHER; PTHR24020:SF14; MATRILIN-4; 1.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF14670; FXa_inhibition; 2.
DR   Pfam; PF10393; Matrilin_ccoil; 1.
DR   Pfam; PF00092; VWA; 2.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 3.
DR   SMART; SM01279; Matrilin_ccoil; 1.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF58002; Chicken cartilage matrix protein; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF53300; vWA-like; 2.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50234; VWFA; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          44..220
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          356..531
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   575 AA;  63234 MW;  22EA566341846068 CRC64;
     GWNKSLIPVV LKLLKPPITN QENICTLLCF LAGAQPKCKS GPVDLVFLID SSRSVRPHEF
     ETMRKFMIDI LNELDIGPDT TRVGVVQYSS QVRSEFSLKT HSKMDAIVKN INEIIPLAQG
     TMTGLAIKYV MNVAFTEAEG DRPKVPNVAV IVTDGRPQDR VAEVAAEARD KGIEIFAVGV
     ARADMTSLRA MASPPFEDHV FLVESFDLIH QFGLQFQDKL CGVDLCLESE HGCEHICESS
     PGSYHCLCLP GYTLNPDGKT CKAIDLLIDY CSFGNHSCDH ECVSVLGGFN CRCNQGYRLL
     ANGKTCQDMD MCKTVAHGCE HQCVSTPGSY YCICPEGQLL QDDGKSCGTC KSANIDLVLL
     IDGSKSVRPQ NFELVKKFVN QVVDSLDVSA HGTRVGLVQY SSRVRTEFPL NMYHTADEIK
     AAVMKVDYME KGTMTGLALK HMLENSFSEA EGARPASRNI PRIGLVFTDG RSQDDITEYA
     KKAKEAGITM YAVGVGKAVE DELREIASDP VEKHFYYTTD FSAISTIAEN LKLNVCPAES
     QGEIEVKDPC ACESLVEFQQ ATMSSLEQLT QKHIL
//