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Database: UniProt
Entry: A0A3B4B8Y4_9GOBI
LinkDB: A0A3B4B8Y4_9GOBI
Original site: A0A3B4B8Y4_9GOBI 
ID   A0A3B4B8Y4_9GOBI        Unreviewed;       159 AA.
AC   A0A3B4B8Y4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000026172.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000026172.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC       that mediates the release of intracellular calcium.
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU368044}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC       extremity. Its large N-terminal cytoplasmic region has the ligand-
CC       binding site in the N-terminus and modulatory sites in the middle
CC       portion immediately upstream of the channel region.
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC       {ECO:0000256|RuleBase:RU368044}.
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DR   AlphaFoldDB; A0A3B4B8Y4; -.
DR   STRING; 409849.ENSPMGP00000026172; -.
DR   Ensembl; ENSPMGT00000027872.1; ENSPMGP00000026172.1; ENSPMGG00000021106.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   PANTHER; PTHR13715:SF52; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1; 1.
DR   PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 1.
DR   SUPFAM; SSF82109; MIR domain; 1.
DR   PROSITE; PS50919; MIR; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU368044};
KW   Calcium channel {ECO:0000256|RuleBase:RU368044};
KW   Calcium transport {ECO:0000256|RuleBase:RU368044};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU368044};
KW   Ion channel {ECO:0000256|RuleBase:RU368044};
KW   Ion transport {ECO:0000256|RuleBase:RU368044};
KW   Ligand-gated ion channel {ECO:0000256|RuleBase:RU368044};
KW   Membrane {ECO:0000256|RuleBase:RU368044};
KW   Receptor {ECO:0000256|RuleBase:RU368044};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transport {ECO:0000256|RuleBase:RU368044}.
FT   DOMAIN          82..136
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
SQ   SEQUENCE   159 AA;  18191 MW;  B3243F4E8418D20F CRC64;
     MLVDDRCVVQ PDTGDLNNPP KKFRDCLFKL CPMNRYSAQK QFWKAAKPGG NSTTDAVLLN
     KLHHAADLEK KQNESENRKL LGTIIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT
     LDSAGNEGSW FYIQPFYKLR SLGDSVGRTW CLFQLNYSL
//
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