ID A0A3B4B9G7_9GOBI Unreviewed; 2516 AA.
AC A0A3B4B9G7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000025186.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000025186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR STRING; 409849.ENSPMGP00000025186; -.
DR Ensembl; ENSPMGT00000026827.1; ENSPMGP00000025186.1; ENSPMGG00000020319.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1326..1954
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2138..2441
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2484..2516
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 514..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2516 AA; 286984 MW; 3B95F223D7D8D480 CRC64;
PSSEFLSFAK HCSSVFKHCS SVFKHCSSVF KHTVLLCLNT VLLCLNTVLL CLNTVLLQVS
LLLNGMLDHS FRERSVRKTQ GKQLVEEVLK QWDHLRSWWD SDSASSATPE SKTATLVLLS
KLLQIDSSVC SLKGHAAFRP VFASFTSLLT DMSLPLNLKS QALLVLPFFT TLPNEPLAEL
QKALDALVAS HFPMQSDEFA KGSLHRNNYM DCVRKLLDAL ELSHSPLLLK LMAAILSRDK
KHIMEEQFQT CFQRTAKRAA PEKQLELLSV GYGDVPTNSM VQALTVRVLL PLASHCGTKA
LSDFFVKNVS DIITLLLSRF TKSCETTFEL QLLKKIGLYK LMELLYSRLP KDDVYSKESR
INQAYCGLGK TDGNEMSKAL IKSCFESFTE NMAGESQLLE LRRQFHCAAY NCAIAVISRS
FSEAKFYQGF LFSEKPEKHQ FILENLIDVS RTYHFPIEVE VPLERKKKYV MIRQEANEEN
RGTPPVYLSS QSYMVDSSLS EEMSQFDFST GVQSFSYSSQ NPDGRRRNAT QDTTSSQDAT
VDLEMDELNQ HECMAAMTAL IGHMQRYNIT PKVEPGSVPS DLPPWMKFLQ GKLSNPASPL
NIRLFISKLV INSEEVFRPY ARFWLGPLLQ LVVSETNGGE GIHFMVVDIV VTVLSWTAAA
SPKGNTRDEV LANRLLEFLM KNCFHSKRAV FRHNLEIIRT LVECWKDCLH VPYSLIYDRF
CGTDPNSKDN SIGLQLLGIV LANDLPAYDA TCGIDYNKYI HSLTNNVTYT RYKEVYSAAA
EIIGLILKNM TDRDGVRSFL FDLAATKITS LGKKEMNDKF IICVNKVSKH FPPFMDKFVN
LAFYLLPKLH GVLKTSCLEC VLSRADVIPQ IFMQLKTSGF IQTMSHRDEV RQRVCLDIVH
KILSVLSPVQ LQELLEPVSA FVSHPSPVCR ERMYDILMWI QDNYSDSESM EDDTSVEILN
SAKETLLQGL AEENAGLQLY VRNFWSQEKR LPTATFERMM MVLGSLYTSQ IERCFLSLAT
NLLLEMTSQS PDFQRNMFEY PLSECTFQDY VIDSNWRFRS SVMTPMFVET QSSQGPESVL
SSPSASLKGK LRATQTSLEF SQTQAPGRRS AFNWLTGSSV DTLAEFSLGS ESLSSLMVFD
KKSERQATRK PVGEGFGMRR VAAPTDEVDN RTQAQNEQRR NILRLRRRFL KDQEKVSLDF
AQKEIQQQRQ KKRLRKEAQV TLYRSYRVGD FPDVQIPHSS LITPLQALAQ KDPILAKQLF
SSLFSGILHE MQKSKTSEEG QSMKDALRCH MDSFLKKMTL CFPPFVACVQ DMCYQHKEML
HIDPANISSS CLVSLQQPSG ILLLEEGLLH TFVPTEPPSK RSRGPKELPP DTNKWIHLAR
LYRSLEDYDI VRGIFGSKVG TKSITCSALQ AESENDYAEA VKLYNEALNT EAWTEAPPTD
AERDFWEIAA MEAYRHLTEW ESLQYCSTVC IDEASPPDLE KMWAEPYHQD LYLRHMICSM
LKQLQLGGAD QTLLSFIDKA MKVEHRKKLL ENHYSQELSL LYILQEDHDR AKYYVNYAMQ
LFMQNYSSVD TLLTKSRLTL LQSAQALTEI QDFLLFVKGE VTVSSLKRLT RLWTERYPDP
KVDPVNVWDD IITSRCFFLD KILEKLNKQG SSDDMEVDEP DINSVVNNCK FSMKLQMAES
AWSQNNFPVA TKLLKDLHRD AKSNRSWFLR WVHSYSRFNH KRSHTLSPVE QISSMLKTVP
LLDLNVRNFC SIFRNQKLLQ GASFHIIATA VGSSRSVLGT IETDKAKKVV RLSGKTWPED
PEVNGAFLYV KAEEELQSYD QDCVEPASLI ETFMALANFC DKRLREEEQR ESDLAALSAH
IVQNMLKALK LNSEEARLKF PRLLQIIELY PSETLDLMTK EMMSVPCWML IGWISQMVAL
LDKPEAVAVQ HCVEQIARSY PQALVYALMI SSESFQFEES ATGHQHRQFV NRLKTKLDEG
GAVKEFVEAL QQLTNPDMIF KDWWDSVKNQ LDKSGFNKKQ MDGLYKEMFS SLGNQNTQRH
GAFRRKFIQK FAKDVERLFG ANGSKLFEKR KDKSFVKEVD DLATSMKTFQ KEPGNLKEYS
PWLSSFKRGP LSDELEIPGQ YDGRSKPLPE YHAKITGFDE RVKVMSSLRR PKRLIIRGDD
ERDHPFLVKG GEDLRQDQRI EQLFGVMNIV LSHDSACTRR GLQLRTYQVI PINTRSLIGL
IEWMENTCTL KDFLTNTMTD KEQKTARRKA SRSDVVKNFH KVLQLVPHDL LKRAFLKMCH
GPEAYLSLRS HFISSHALLC VSHWVLGIGD RHLSNFMINT ETGGVIGIDF GHAFGSATQF
LPVPELMPFR LTQQFVKLME PLQESGLIQS IMVHSLRAFR AEPDLLLNTM DVFVKEPSLD
WKNFERKQLK KGGTWTKEVD TKEINWYPLQ KVNFARRKLE GANPAAVTSE ELKLGFEKDP
AFQGLQSVAI GTRGVNVRAD VPAEALSVEK QVDCLLDQAT DPNVLGRVWV GWEPWV
//
