ID   A0A3B4BC13_9GOBI        Unreviewed;       701 AA.
AC   A0A3B4BC13;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha {ECO:0000256|ARBA:ARBA00013911};
DE   AltName: Full=Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha {ECO:0000256|ARBA:ARBA00031433};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000027297.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000027297.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC       {ECO:0000256|ARBA:ARBA00009442}.
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DR   AlphaFoldDB; A0A3B4BC13; -.
DR   STRING; 409849.ENSPMGP00000027297; -.
DR   Ensembl; ENSPMGT00000029082.1; ENSPMGP00000027297.1; ENSPMGG00000022038.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd12924; iSH2_PIK3R1; 1.
DR   CDD; cd09930; SH2_cSH2_p85_like; 1.
DR   CDD; cd09942; SH2_nSH2_p85_like; 1.
DR   CDD; cd11910; SH3_PI3K_p85alpha; 1.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 2.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR044124; ISH2_PIK3R1.
DR   InterPro; IPR032498; PI3K_P85_iSH2.
DR   InterPro; IPR035591; PI3K_p85alpha_SH3.
DR   InterPro; IPR035020; PI3kinase_P85_cSH2.
DR   InterPro; IPR035022; PI3kinase_P85_nSH2.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR   Pfam; PF16454; PI3K_P85_iSH2; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00017; SH2; 2.
DR   PRINTS; PR00678; PI3KINASEP85.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00252; SH2; 2.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF55550; SH2 domain; 2.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50001; SH2; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          3..79
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          308..403
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          601..695
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          79..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          424..451
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   701 AA;  79866 MW;  AF122200F91684AE CRC64;
     MTSEGFQYRA LYDYKKEREE DIDLHVGDVL LVSKAALLAL GCTNGAEERP AEIGWLPGFN
     ETTQEKGDFP GTYVEFVGRK RMSPPTPKPR PPRPPSAASA RADSESEGEC FVLPDLPDQF
     GPPDTAPPLL SRLMEAVETK GVSDALPSSC IPVCQMPSRP PVSLCYQLKS VLLSLSMCVI
     ICVSCADVRE LEECAQLLRT IASSSLTPAQ YGLTLLSVIR HLARVCLHNH RNQLNPHGLA
     DGFSPLLFRN NTGAESGVDP MVQVLEILIT SELNMNQAAP ALPPKPPKPA APAASTFNNS
     ISLQDAEWYW GDISREEVNE KLRDTADGTF LVRDASTKMH GDYTLTLRSG GNNKLIKIFH
     REGKYGFSDP LTFSSVVELI NHYRHESLAQ YNPKLDVKLL YPVSKHQQDQ VVKEDSIEAV
     GKKLHEYHLQ YQEKNREYDR LYEEYTRTSQ EIQMKRTAIE AFNETIKIFE EQCQTQERFS
     KEYIEKFRRE GNDKEMQRIM ENYDKLKSRI SEIVDSKRHL EVDLKKQAAD YREIDKKMNS
     IKPDLIQLRK TRDQYLMWLT QKGVRQRKLN EWLGLKNETT EDEYSLVEDE EDLPHHDERL
     WRLGNINRTQ AESLLRGKRD GTFLVRESSK PGCYACSVVV DGEVKHCVIN KTSSGFGFAE
     PYNLYSSLKE LVLHYQHTSL VQHNDSLNVT LAFPVYSQQR R
//