ID   A0A3B4BFR0_9GOBI        Unreviewed;       370 AA.
AC   A0A3B4BFR0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000027366.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000027366.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR   AlphaFoldDB; A0A3B4BFR0; -.
DR   STRING; 409849.ENSPMGP00000027366; -.
DR   Ensembl; ENSPMGT00000029156.1; ENSPMGP00000027366.1; ENSPMGG00000022082.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475}.
FT   DOMAIN          11..280
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   370 AA;  42034 MW;  69107C5A58AB6249 CRC64;
     MSGEQRGLVY LITGGCGFLG KHILRVLLEK EREVVSEIRV FDKHSDPSLE EESTEHTKVV
     VIQGDITDYT QVLEVSRGVD VFIHSASAVD VWHKIPESVM YKVNVKGTDL VIQACVENGI
     TSLIYTSSMG VIGPNQDGDP FIRGSEDTPY RTKLTMPYDK TKAEAEQMVL KANGTKVNGG
     KMLYTCSLRP TGIYGEGHEL LKEFWERCVN LGGVHVGAVP SNTEHGRVYA GNVAWMHVLA
     ARTLRDKPQS VAGEVYYCYD DSPYSSYENF NLQFFTSSNF RHIQLPFVVV WFIAIMNDIL
     RWILSPFYNY TPLLNLYTFR TAVTSFTVST DKAYRHFQYK PLYSWEECKK RTQEYIRNSG
     NLDCSDNQDL
//