ID   A0A3B4BGF7_9GOBI        Unreviewed;       853 AA.
AC   A0A3B4BGF7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Cadherin-related family member 1 {ECO:0000256|ARBA:ARBA00044073};
DE   AltName: Full=Photoreceptor cadherin {ECO:0000256|ARBA:ARBA00044253};
DE   AltName: Full=Protocadherin-21 {ECO:0000256|ARBA:ARBA00044335};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000027906.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000027906.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR   AlphaFoldDB; A0A3B4BGF7; -.
DR   STRING; 409849.ENSPMGP00000027906; -.
DR   Ensembl; ENSPMGT00000029723.1; ENSPMGP00000027906.1; ENSPMGG00000022498.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 4.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   PANTHER; PTHR24027:SF413; CADHERIN-RELATED FAMILY MEMBER 1; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        690..715
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          32..125
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          126..237
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          238..344
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          350..463
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          464..566
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          568..679
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          731..752
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   853 AA;  94668 MW;  D2F3425E2FAD4DF6 CRC64;
     LLYLSMFYTQ ADFGPYFYDN GPYSKNGNMA LFSLSEDTPV GTQIYCLNGT DPEGNTVSYG
     LSFDPGTKQY FRVNPRTGNV TLIEPLDRER KDSLDVLVSI SDGQSKVEER VTVFIMDTND
     EKPEFQNLPG MTSVLETTEP DTSIYRVDAI DRDTGSGGSV TYFLQDPSSS LFTIDRYSGI
     LKIKSGETLD YEKSKTHFVT VIAKDGGGNY KGKEQFLSSS ATLTINVIDA QDTPPIFIGT
     PYFGYVYEVT SPGSEIFHVE AKDGDVGSPN SVQYSFDEGA DGVFSINKSN GRITLLTSPA
     NLRREIFNIR VRATEVSTDG VLLDHSSTTV VIRVVDLNNN PPTFYGENGP QNMFELTMHE
     HPPEGEILRG LKITVNDSDQ GANAKFNLRL LGPGRMLRVV PQTVLNEAQV TILVDDSAAM
     DYERHHFLTF KLLAVEVDTP ERFSATADIV IHLLDTNDNA PKFSAEYYIA RIPENSPGGT
     DVVTVTASDP DSGPWGDVKY SLYGSGADFL IQPASGIIYT QPWASLDAEV RSKYNFYVKA
     EDAEGKYSVA EVFLTVLDLN DHPPAFNQNL MEKTMVIGAP VKIEAVDDDA EIPNNVIQYT
     IMKAEPDPNI FDINADTGEI NLKSYIKSLA IIQNITNKRD YSWSLVVQAR DRGQPSFSTT
     AVVKIDITEA TKLSGGPLST MIMQSRNKPL HVLGMLGGAI CLMIIVTVLI STVMFMRTKK
     SNRILPNRRI RRRKTQPQKP WISSPFKRQD PDKFKVDEVE HEPETAAENV NSNNNVSSVV
     RIWPPPPPPC APSLPPPPPL SFTRDKQWTV PTVSAHVVPK PRKKPAMTRQ DTVNKALVSE
     LKLRLEQKRL NYQ
//