ID A0A3B4BHV1_9GOBI Unreviewed; 454 AA.
AC A0A3B4BHV1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000029179.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000029179.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3B4BHV1; -.
DR STRING; 409849.ENSPMGP00000029179; -.
DR Ensembl; ENSPMGT00000031061.1; ENSPMGP00000029179.1; ENSPMGG00000023417.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19395; TGF_beta_BMP5; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR NCBIfam; NF033679; DNRLRE_dom; 1.
DR PANTHER; PTHR11848:SF139; BONE MORPHOGENETIC PROTEIN 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..454
FT /note="TGF-beta family profile domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017185118"
FT DOMAIN 334..454
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 317..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 51042 MW; 1C8F9F5E71474E8E CRC64;
MTVLASLNCA VLGIAWSLSF LSCAHCGLSD HHVHSSFIYR RLRNHERKEI QREILSILGL
PHRPRPFSPG KQSSSAPLFM LDLYNAMSVE EESAYHGTGK GFSAKAAGQS RKAYYSPQGN
GYSRMAQPYR AAPLLGHNPA LTTAHDTNFL NDADMVMSFV NLVEKDKDFS HQRRHYKEFR
FDLTQIPEGE AVTAAEFRIY KDRSHSRYDN ITLKISIYQV IKEYQNKDAD TFLLDFKKVQ
ASDGGWLGFD ITATSNHWVM NPQHNLGLQL CVETADGRSI NTKSAGIIGR NGPQSKQPFL
VAFFKASGVL LRSVRATGGK KKNHNRNKSN NQQESSRAPK SGDYNTSEQK QACKKHELYV
SFRDLGWQDW IFAPEGYAAF YCDGECAFPL NAHMNATNHA IVQTLVHLMF PNNVPKPCCA
PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH
//
