ID A0A3B4BJL2_9GOBI Unreviewed; 1343 AA.
AC A0A3B4BJL2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPMGP00000028971.1};
OS Periophthalmus magnuspinnatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000028971.1, ECO:0000313|Proteomes:UP000261520};
RN [1] {ECO:0000313|Ensembl:ENSPMGP00000028971.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 409849.ENSPMGP00000028971; -.
DR Ensembl; ENSPMGT00000030840.1; ENSPMGP00000028971.1; ENSPMGG00000023311.1.
DR Proteomes; UP000261520; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 4.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..33
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 197..289
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 366..386
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 392..506
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 651..748
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 752..933
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 962..1056
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 35..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1311..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1343 AA; 153810 MW; F6CE72D000374879 CRC64;
LLFLDQDSLL SLGITATGHR KRILRLIGHL QRTYCPQPTN QSTPMLDSKD PRRLGLKPVP
KPRTVFNRRR TTPVHFAPSS HDQHKPLRRL SPQSLSLDSE NLPRSDAMEM VSNEIYWGAT
LSGRGYRMFM QLCFVSILTF SSSTNLVMGD GVLQLCVLSP QSLWLKRLSP HEALPPHLDD
DIISPYASYT SLNDKAPPVL SGWLDKLSPQ GNYVFQKRFV KFDGQNLMYY GHEKDAYPKG
VIPLAVIQMA RPSKDNKFEI VTSNRIFVFR ADNEVLRSRW VRTLQDFIRE QLVFVRRRFG
PGLHCQKHGP LETKGHKSKV YTAIYGDQIW IHKNQQVRSR EAGPEQSQRS RQEQSQRSKF
CLWSSFIAES EREKREWTEA LQEAISETLS DYEVAEKIWS NKSNRVCADC RALNPDWASI
NLCVVICKNC AGQHRSLGTS VSKVQSLKLD TSVWSNQIVQ LFIMLGNDRA NEFWASRLPS
SEELDCDAAP ELRREFISLK YREGRWRSPH PIFSSQPQLL KVCSAQLHLL KHMCQTQGPR
AKCGPPHHFM WPSTGMCPLH TAPCEDSCAL CVSDFQRFWC SVDRSLVLFE TEMSPDPVLN
INYRDLLCLG VSRPDGSKRR TPFTFSPVCF HLVLCLQAFT PLSCHCLLSR EFERVGVLRY
RAMLDPQQWR DAFFVLQKSN LFICPSTDGA AEDIINLRRL QELSVSSEGE GEKKDTLVLV
ERGRTLHLQG VARTDFSLWC ADIQRASGGR GNSLREQQLS RNDIPIIVDS CIAFITQYGL
GHEGIYRKNG AKSRIKLLMD EFRKDARNVK LRIGDHFIED VTDVLKRFFR EIDDPIFMSD
LHPLWQEAAK IPQKSQRLDR YKEIIRSLPR VNRTTLAALI SHLYRVQKCA DLNHMCTKNL
SLLFAPSLFQ TDGKGEHEVK IVEDLIDNYL YVFDIDEEHQ TQMDLEINLI TSWKDTQLSQ
AGDLIIEVYL EMKIPDCCIT LKVSPTMCAE ELTNQVLYLR NVPPSDRDVW MTFEAIEDGQ
LERPLHPKER VLEQALQWCN MADPSSAFLI VKKVPKEDAI NIFTSYKSEV MKVGLLRCRE
EPPKLLQGNK FQERTFQIQG NKLRLLKDKK SIKPEKEWSL KSMKIYIGIR KKLKAPSRFL
CCSGEAELWD WITCFLKAQN NEAAPAILRR HSSSDISKQK FGTMPLVPIR GDESNSSMLS
ANQTLRKLHD RRTLSMYFPM TAQPEEDPVP EPDSFGEPLY EEVGDFGLQV LQSLQTSFRT
SIAAETQEVP AHSHLHLLAT ETGSCQVIAD EQLDSLSSPS SEELLLKELQ TALGKSVEEE
QAPEDQQTPE QRTVEEEERP YDV
//
