ID   A0A3B4BK34_9GOBI        Unreviewed;       186 AA.
AC   A0A3B4BK34;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Insulin-like domain-containing protein {ECO:0000259|SMART:SM00078};
OS   Periophthalmus magnuspinnatus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Oxudercinae; Periophthalmus.
OX   NCBI_TaxID=409849 {ECO:0000313|Ensembl:ENSPMGP00000029131.1, ECO:0000313|Proteomes:UP000261520};
RN   [1] {ECO:0000313|Ensembl:ENSPMGP00000029131.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC   -!- SIMILARITY: Belongs to the insulin family.
CC       {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR   AlphaFoldDB; A0A3B4BK34; -.
DR   Ensembl; ENSPMGT00000031007.1; ENSPMGP00000029131.1; ENSPMGG00000023432.1.
DR   Proteomes; UP000261520; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   CDD; cd04368; IlGF; 1.
DR   Gene3D; 1.10.100.10; Insulin-like; 1.
DR   InterPro; IPR022341; IGF-I.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR022350; Insulin-like_growth_factor.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR46845:SF3; INSULIN-LIKE GROWTH FACTOR 1; 1.
DR   PANTHER; PTHR46845; INSULIN-LIKE GROWTH FACTOR I; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR02002; INSLNLIKEGF.
DR   PRINTS; PR02005; INSLNLIKEGF1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; Insulin-like; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406}.
FT   DOMAIN          47..103
FT                   /note="Insulin-like"
FT                   /evidence="ECO:0000259|SMART:SM00078"
FT   REGION          107..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..151
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        50..90
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT   DISULFID        62..103
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT   DISULFID        89..94
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ   SEQUENCE   186 AA;  21255 MW;  71AAA99947226F96 CRC64;
     VMSYALFFHW HLCDVFKSVM CCILCSHALS LLCVFTLTPA AAGAGPETLC GAELVDTLQF
     VCGDRGFYFS KPTGYGPNSR RSRGIVDECC FQSCELRRLE MYCAPSKTNK PPRSVRSQRH
     TDVPRPAKVS TAEQVDKRSE RRTAKQPDKP KNKKVSIRRK KKHLLQRYIL QSWYTGKMLD
     HLDQHL
//