ID A0A3B4BKF9_PYGNA Unreviewed; 1065 AA.
AC A0A3B4BKF9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Adhesion G-protein coupled receptor D2-like {ECO:0000313|Ensembl:ENSPNAP00000000028.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000000028.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000000028.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR RefSeq; XP_017542698.1; XM_017687209.1.
DR AlphaFoldDB; A0A3B4BKF9; -.
DR Ensembl; ENSPNAT00000014542.1; ENSPNAP00000000028.1; ENSPNAG00000007218.1.
DR GeneID; 108414364; -.
DR CTD; 347088; -.
DR GeneTree; ENSGT00940000161534; -.
DR OMA; SCEQQFG; -.
DR OrthoDB; 4219275at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF58; ADHESION G-PROTEIN COUPLED RECEPTOR D2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1065
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017295383"
FT TRANSMEM 719..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..773
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 785..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 918..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 943..963
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 717..964
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 994..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 118067 MW; 6F91847861AE69FA CRC64;
MPPVLLMVIL VKAMAVGICE PVQSGPDSSE RCLAGPGDQS HVFLSSHTVF QLVNASCSFS
QAWHYCQSRF SSITVLGQLE DEDGIKQLLN QANMQGPIWV RISNSLAPTS TVTLSKQNVL
LSALSFTGDS TYGHARARAI FPPLASASTC ARVQFDARHE SVSTLFSYAT RALTNEFQLR
ARADETRRRV LLAPIVHGRH HAYRASFPND ARWHHVCVTW RKSDGLWAVY VDGEKGEWGT
GTEPSRDMHG HGIFVLGQDQ DSFGGNFTEP FVGNITDVNF WDVTLDDEQI RRLEDCTSPL
EPKPLFSWQE LNLTLHEVKE VAAVMQCPGL LKQKQREQED CRVLDGWTQA VAQYSTTPCS
HTLPFICKTS KERYVKKKEL EESQSAHPSP FLQHLMKHGV NTGDVLGMPD ADESWESVTN
LLNISDQYLR GSREQLESRD FPSLVQMLSR ATELPTTGNQ SLTNARMLSH SFIGLADTLI
SQENADKWQA IREVVSGPMA VVHTIDRMVT NLSPLLLGDT DSVHIHFNNI RMQVQEKTVS
ESTGGSEFCS SDWINNTDLD CISVPPQSMQ ELHNNGFGKV TVLSTWYSSL KPLMNKEENI
TVVPTITDGS LKYMGTVLGS SVISSAVVGD GQLISLGVQF KLQHRTQNTS GMFYYPICAF
WDFSLTPEDG GGWSTEGCEV ISLQQDSTSC YCNHTTNFAL LLQIYDVQWS QENEKGLQIL
SFIGCGVSLC GLIFTFILFI AVGVPKSDRT TVHKNLIVAL ALAQLLLIFS YWASANQELC
LMVTALLHLF FLSSFCWMLV EGLLLWSKVV SVNISEDRRM RFYYALGWGL PLFIVAVTLM
VSLNKYKAEQ HCWLNTESDI IWAFVGPVLF VLAVNTVVLC RVVVVTVSSA RRRAKMLAPS
SASKPHTLDL TWAATRPVLI LLPVLGLTWL CGILVHLSVV LAYLFIALNA FQGLYIFLVY
AVYNSEVQNA IKRIQEKRKA LSFTNCSQPI SFLPSQKTPG ASWADSLPTP SSPESSGSSH
ITNSMSSSLI FKNESFGTDS FVNFSLKPAA GNQVVQLMAF KPSAC
//
